Inflammatory Markers as Predictors of Multi-Organ Involvement in Chronic Diseases: A Prospective Observational Study.

Rajeev  Kumar; Dr. Rajeev  Ranjan; Shachindra Kumar  Astik

doi:10.51168/sjhrafrica.v7i3.2490

Authors

Rajeev Kumar Senior Resident, Department of General Medicine, Nalanda Medical College and Hospital, Patna, India,
Dr. Rajeev Ranjan Senior Resident Department of General Medicine, Nalanda Medical college and Hospital, Patna, India,
Shachindra Kumar Astik Professor, Department of General Medicine, Nalanda Medical college and Hospital, Patna, Bihar,

DOI:

https://doi.org/10.51168/sjhrafrica.v7i3.2490

Keywords:

Inflammatory markers, CRP, IL-6, NLR, multi-organ involvement, chronic disease.

Abstract

Background:

Chronic diseases are often associated with persistent systemic inflammation, which may contribute to progressive multi-organ dysfunction. Inflammatory biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), and neutrophil-to-lymphocyte ratio (NLR) have been proposed as potential indicators of disease severity and organ involvement.

Objective:

To evaluate the predictive value of inflammatory markers (CRP, ESR, IL-6, and NLR) for multi-organ involvement among patients with chronic diseases.

Methods:

A prospective observational study was conducted over a 12-month period at Nalanda Medical College and Hospital, Patna, India. A total of 100 adult patients diagnosed with chronic diseases were included. Baseline inflammatory markers, including CRP, ESR, IL-6, and NLR, were measured. Organ involvement (cardiac, renal, hepatic, and pulmonary) was assessed through clinical evaluation, laboratory investigations, and imaging studies. Statistical analysis included descriptive statistics, independent t-tests, Pearson correlation analysis, and logistic regression to determine associations between inflammatory markers and organ involvement.

Results:

Multi-organ involvement was observed in 46% of patients. Mean levels of CRP, IL-6, and NLR were significantly higher among patients with involvement of two or more organs (p < 0.001). IL-6 demonstrated the strongest correlation with the number of organs involved (r = 0.62), followed by CRP (r = 0.58).

Conclusion:

Elevated inflammatory markers, particularly IL-6 and CRP, are strong predictors of multi-organ involvement in patients with chronic diseases and may serve as useful tools for early risk stratification.

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