Arterial blood gas analysis in chronic kidney disease, acute exacerbation of chronic obstructive pulmonary disease, and acute coronary syndrome. A cross-sectional observational study.
DOI:
https://doi.org/10.51168/sjhrafrica.v6i12.2441Keywords:
Arterial blood gas (ABG), chronic kidney disease (CKD), Acute exacerbation of chronic obstructive pulmonary disease (AECOPD), Acute coronary syndrome (ACS)Abstract
Background:
Arterial blood gas (ABG) analysis plays a critical role in evaluating acid–base disturbances in emergency patients with chronic kidney disease (CKD), acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and acute coronary syndrome (ACS).
Methods:
Three observational cross-sectional studies were conducted at Darbhanga Medical College and Hospital between 2020 and 2025 involving 420 patients. ABG parameters were assessed at admission and correlated with clinical outcomes.
Results:
No linear correlation was observed between estimated creatinine clearance and pH in CKD patients. In AECOPD, ABG-guided management significantly reduced hospital stays and improved survival (96.7% vs 81.7%, p=0.023). In ACS, metabolic acidosis was present in 42% of patients and was associated with higher mortality (40.5%). A strong association between pH correction and clinical improvement was noted (p<0.001).
Conclusion:
Routine ABG-guided management significantly improves outcomes across CKD, AECOPD, and ACS.
Recommendation:
Regular ABG monitoring should be incorporated into emergency protocols for early diagnosis and targeted intervention.
References
Das RK. Accuracy of arterial blood gas: a quality improvement study. Int J Med Biomed Stud. 2024;8(6):63–69.
Akhilesh Kumar D, et al. Evaluation of arterial blood gas–guided management of acute myocardial infarction. 2024;15(9).
Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2024 report.
Das RK. Relation between arterial blood gas values and outcomes of patients admitted with acute exacerbation of chronic obstructive pulmonary disease. GIS Sci J. 2023;10(6):403–414.
Shivram SD, Sudharsan S. Correlation between clinical features, spirometry, and arterial blood gas in acute exacerbation of obstructive lung disease. Cougl. 2021;11(4):46–52.
Das RK. Relation between estimated creatinine clearance and acid–base balance status in chronic kidney disease patients. J Cardiovasc Dis Res. 2021;12(4).
Das RK. Arterial blood gas: gold standard in emergency department. J Med Sci Clin Res. 2019;7(11):660–650.
Kraut JA, Madias NE. Metabolic acidosis of chronic kidney disease: an update. Am J Kidney Dis. 2016;67(2):307–317.
Shoaib A, et al. Clinical characteristics, management strategies, and outcomes of non-ST-segment elevation myocardial infarction patients with and without prior coronary artery bypass grafting. J Am Heart Assoc. 2021;10.
Stukel TA, et al. Association between hospital cardiac management and outcomes for acute myocardial infarction patients. Med Care. 2010; 48:157–165.
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Copyright (c) 2025 Dr. Ravindra Kumar Das, Dr. Prashant Kumar, Dr. Kunal, Dr. Mukesh Kumar Kushwaha, Dr. Pramey Prashant, Dr. Akhilesh Kumar, Dr. Praneet, Dr. Rajeev Ranjan
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
