A Retrospective Cohort Study Statin Lipophilicity and the Risk of Developing Heart Failure

Brajesh Kumar  Singh

doi:10.51168/sjhrafrica.v5i12.1472

Authors

Brajesh Kumar Singh MD Medicine, Associate Professor, Department of Medicine, Lord Buddha Koshi Medical College and Hospital, Saharsa, Bihar, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i12.1472

Keywords:

Statins, Lipophilicity, Heart Failure, Cardiovascular Risk, Statin Therapy

Abstract

Background: The cornerstone of the battle against cardiovascular disease is statin medication, which lowers cholesterol. In recent research, there has been considerable discussion regarding whether lipophilicity of statin raises the risk of heart failure. Examining the relationship between incident heart failure and statin lipophilicity is the aim of this retrospective cohort investigation.

Methods: For this retrospective cohort study, electronic health records were utilized. Every participant had to be at least eighteen years old and have a history of taking statins. The two types of statins were classified as less lipophilic and highly lipophilic. Heart failure rates were assessed during the study. A statistical model accounting for confounding variables was used to compute hazard ratios and 95% Confidence Interval.

Results: Those on highly lipophilic statins had a slightly greater overall rate of heart failure (3.3 cases per 1,000 person-years) than those taking less lipophilic statins (2.5 cases per 1,000 person-years) in our study of 100 patients. The association between highly lipophilic statins and an increased risk of heart failure was not statistically significant (Hazard Ratio: 1.31, 95% CI: 0.88 - 1.95).

Conclusion: In line with earlier studies, this study highlights the complex relationship between lipophilicity of statin and the heart failure risk. Even though there was no statistically significant trend, the complex nature of the link necessitates more research in bigger, more representative cohorts. Clinicians should consider the unique characteristics of each patient while prescribing statins in the absence of conclusive proof.

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