PREVALENCE OF CELIAC DISEASE AMONG CHILDREN WITH SHORT STATURE IN A TERTIARY CARE HOSPITAL.

Authors

  • Rajiv Kumar Mahli Assistant Professor, Department of Biochemistry, SBMC, Hazaribagh, Jharkhand, India
  • Anil Kumar Assistant Professor, Department of Medicine, SBMC, Hazaribagh, Jharkhand, India
  • Chhitiz Anand Assistant Professor, Department of Paediatrics, SBMC, Hazaribagh, Jharkhand, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i3.1119

Keywords:

Celiac Disease, Short Stature, Anti-Ttg Antibody

Abstract

Back ground:

Celiac disease (CD) is the most common genetically related food intolerance worldwide and is triggered by a well-identified environmental factor (gluten and related prolamines present in wheat, rye, and barley), and the autoantigen is also well known (i.e., the ubiquitous enzyme tissue transglutaminase).

Methods:

A retrospective cross sectional study was carried out at the department of Pediatrics, SBMC, Hazaribagh. All children who were evaluated for short stature in a period between November, 2021 to October, 2023 were included in the study as per inclusion criteria. Their medical documents were retrieved from the medical records section and analyzed. Enzyme immunoassay was used to determine IgA tTG using microplate tests as per standard unit protocol and those children with concentrations >20U/mL were defined as positive. Patients with positive anti-tTG serology had also been subjected to endoscopy and biopsy as per standard celiac disease work up.

Results:

Medical documents of 103 patients with short stature were evaluated. 40 of them were included in our study according to inclusion criteria; 26(65%) were female and 14 (35%) were male. Median age was 9 years (from 2 - 18 years).The anti-tTG assays were positive in 20% of patients (8/40). Out of 8 patient who had positive titres of anti-tTG, 6 (75%) were diagnosed as celiac disease by endoscopy and biopsy according to modified Marsh classification. All children diagnosed to have celiac disease were kept on a gluten-free diet. Follow-up anthropometric data for six months as recorded in medical documents were analyzed and showed improvement in growth rates.

Conclusion:

Celiac disease is a cause of short stature that should be included in diagnostic investigations of short stature.

Author Biography

Anil Kumar, Assistant Professor, Department of Medicine, SBMC, Hazaribagh, Jharkhand, India

 

Published

2024-03-31

How to Cite

Mahli, R. K., Kumar, A. ., & Anand, C. . (2024). PREVALENCE OF CELIAC DISEASE AMONG CHILDREN WITH SHORT STATURE IN A TERTIARY CARE HOSPITAL. Student’s Journal of Health Research Africa, 5(3). https://doi.org/10.51168/sjhrafrica.v5i3.1119

Issue

Section

Section of Pediatrics and Child Health

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