Use of Pre and post treatment comparison of intra-lesional infiltration of dexamethasone plus hyaluronidase in management of patients with OSMF.

Authors

  • Dr Vijaya Bala Murmu Senior Resident,ENT Shaheed Nirmal Mahato Medical College and Hospital, Dhanbad
  • Dr Ragini Kullu Senior Resident, Dept. of ENT, SBMCH, Hazaribagh

DOI:

https://doi.org/10.51168/sjhrafrica.v5i11.1771

Keywords:

Oral Submucous Fibrosis, Dexamethasone, Hyaluronidase, Intralesional therapy

Abstract

Background: Oral Submucous Fibrosis (OSMF) is a chronic, progressive, and potentially malignant disorder characterized by fibrosis of the oral mucosa, leading to trismus and burning sensation. Intralesional injections offer a localized approach to treatment with fewer systemic effects.

Aim: To evaluate and compare the pre- and post-treatment outcomes of intralesional dexamethasone and hyaluronidase in the management of OSMF.

Materials and Methods: A tertiary care centre conducted one-year prospective interventional research on 50 clinically confirmed OSMF patients. Each patient received biweekly intralesional dexamethasone (4 mg/mL) and hyaluronidase (1500 IU) injections for six weeks. Mucosal flexibility, mouth opening, and VAS were measured before and after therapy.

Results: There was a statistically significant increase in mean mouth opening (from 23.4 ± 4.1 mm to 31.2 ± 3.8 mm) and a marked reduction in VAS scores for burning sensation (from 7.3 ± 1.1 to 2.1 ± 0.9). Mucosal flexibility improved in 86% of patients.

Conclusion: Intralesional dexamethasone combined with hyaluronidase effectively improves clinical outcomes in OSMF patients, showing significant symptomatic and functional benefits.

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Published

2024-11-30

How to Cite

Murmu, V. B. ., & Kullu, R. . (2024). Use of Pre and post treatment comparison of intra-lesional infiltration of dexamethasone plus hyaluronidase in management of patients with OSMF. Student’s Journal of Health Research Africa, 5(11). https://doi.org/10.51168/sjhrafrica.v5i11.1771