Prevalence and antimicrobial susceptibility of helicobacter pylori and associated factors among symptomatic Patients at Butagaya health center iii, Jinja district

Lucy  Apeduno; Manusuli  Kaiga; Expedito  Kasumba; Adonia  Kyakulaga; Ambrose James  Omar; Rogers Kalyetsi; Fred Sempijja; Buga  Rudolf; Robert Gumisiriza; Salome  Nyiramahoro

doi:10.51168/sjhrafrica.v6i6.1533

Authors

Lucy Apeduno Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Manusuli Kaiga Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Expedito Kasumba Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
Adonia Kyakulaga Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Ambrose James Omar Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Rogers Kalyetsi Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Fred Sempijja Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Buga Rudolf Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
Robert Gumisiriza Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Salome Nyiramahoro Department of Medical Laboratory Sciences, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.

DOI:

https://doi.org/10.51168/sjhrafrica.v6i6.1533

Abstract

Background: H. pylori infection rates are higher in resource-poor settings and developing countries such as Uganda. Despite the fact that most health facilities in Uganda including government health facilities have put in place a number of measures including diagnostic methods for H. pylori and antibiotics used in treatment and management of H. pylori infection,

Methods: The study employed a cross-sectional design that involved 384 individuals at the Outpatient department at Butagaya Health Centre III, who presented with signs and symptoms of H. pylori infection; selected using simple random sampling. H. pylori antigen tests, an interviewer administered structured questionnaire and disc diffusion were used to obtain data,

Results: The study found that 22.4% of respondents were positive H. pylori tests. However, growth was only registered on 9(10.5%) of which, 4(44.4%) were susceptible and 5(55.6%) were resistant. Of the resistant samples, 1(20.0%) was resistant to Clarithromycin, 2(40.0%) to Metronidazole, 1(20.0%) to Levofloxacin and 1(20.0%) to Tetracycline; 2(40.0%) were resistant to only one antibiotic, 2(20.0%) had dual resistance (1(50.0%) to Clarithromycin and Metronidazole, 1(50.0%%) Levofloxacin and Metronidazole) while 1(20.0%%) had multiple resistance to Clarithromycin, levofloxacin and metronidazole. Age, gender, marital status and source of drinking water had a significant association with H. pylori infection (p<0.05).

Conclusion: The prevalence of H. pylori was established at 22.4%. Full susceptibility to antibiotics was established at 44.4%. The highest resistance was to Clarithromycin and dual resistance to Clarithromycin + Metronidazole and Levofloxacin + Metronidazole. Age, marital status, gender and source of drinking water were the only factors found to be significantly associated with H. pylori infection

Recommendations: Individuals should take care to obtain water from safe sources, culture and sensitivity should always be performed for all suspected H. pylori infections and clinical trials should be done to guide the development of new antibiotics

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