A HOSPITAL-BASED OBSERVATIONAL STUDY ON THE SURVIVAL OUTCOMES OF PATIENTS WITH HIGH-GRADE GLIOMA ABOUT DIVERSE PROGNOSTIC FACTORS.

Kashyap  Shiwangi; Gouda Amiya Kumar; Dhir Kumar Manmath; Das Bidyut Prava; Puhan Arabinda; Madan Mohan Majhi; Behera Sanjay

doi:10.51168/sjhrafrica.v4i12.894

Authors

Kashyap Shiwangi Resident, Dept. of Neurosurgery, SCB Medical College, Cuttack, Odisha, India.
Gouda Amiya Kumar Asst. Professor, Dept. of Neurosurgery, SCB Medical College, Cuttack, Odisha, India.
Dhir Kumar Manmath Professor, Dept. of Neurosurgery, SCB Medical College, Cuttack, Odisha, India.
Das Bidyut Prava Prof. & Head of the department of Pathology, F.M. Medical College & Hospital, Balasore, Odisha, India.
Puhan Arabinda Resident, Dept. of Neurosurgery, SCB Medical College, Cuttack, Odisha, India.
Madan Mohan Majhi Asst. Professor, Dept. of Community Medicine, SCB Medical College, Cuttack, Odisha, India.
Behera Sanjay Asst. Professor, Dept. of Community Medicine, SCB Medical College, Cuttack, Odisha, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v4i12.894

Keywords:

Glioblastoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Gliosarcoma, Prognostic factors of High-Grade Glioma

Abstract

Background:

Despite the treatment available for tumors in the brain, the prognosis of these tumors has a significant effect on the emotional and cognitive abilities of the patients. Early diagnosis and suitable treatment can prevent the worsening of the tumor. The effect of the tumor on the brain leads to a negative impact on an individual’s social life. This necessitates the requirement for a treatment that is reliable and prevents the worsening of tumors. This study aimed to study the various clinical presentations, various imaging features, Immunohistochemical expression of various tumor markers, and the outcome after surgery and adjuvant chemotherapy and radiotherapy and to analyze various prognostic factors of high-grade glioma.

Material & Methods:

This includes 103 cases of High-grade gliomas admitted to the Department of Neurosurgery, SCB Medical College & Hospital, Cuttack between January 20202 to March 2023. Before the resection of the tumor, neurological and radiological examinations were carried out. The extent of removal was determined by running a CT scan after the surgery.

Results:

In the present study of 103 cases, males constituted 62.1% as compared to females who constituted 37.9%. 48.5% of all tumors were found in the frontal lobe, followed by the temporal lobe (32%) of cases. Enhancement was seen in 89% of cases, mostly it was seen in Glioblastomas. Hemorrhage was seen in 40.8% of cases mostly seen in grade 4 gliomas. Lipid lactate peak was seen in 71.8% of cases.

Conclusion:

KPS score, surgical resection, Adjuvant chemotherapy, and radiotherapy showed statistically significant association with the outcome and survival rate.

Recommendation:

Further studies with a larger number of patients, using multiple immunohistochemical markers, and a longer follow-up are needed, which will provide significant data to conclude on the outcome and survival analysis.