INFLUENCE OF PERIOPERATIVE ANTIBIOTIC PROPHYLAXIS ON TIME TO POSITIVITY AND PROPORTION OF POSITIVE SAMPLES: A COHORT STUDY OF 60 CUTIBACTERIUM ACNES BONE AND JOINT INFECTIONS.

Abstract

Background

Cases of suspected bone or joint infections require intraoperative microbiological testing before antibiotic treatment. This theory implies that perioperative antibiotics may induce poor culture findings, hindering personalized antibiotic therapy. In Cutibacterium acnes infections of bone and joints, antibiotic prophylaxis 30–60 minutes before surgery affected the duration and proportion of positive microbiological samples. Determining how perioperative antibiotic prophylaxis affects Cutibacterium acnes bone and joint infection microbiological sample positive time and proportion.

 Methods

A retrospective analysis was conducted including patients with at least one Cutibacterium acnes-positive sample within a year. Patients were classified as exhibiting an "infection" if a minimum of two samples yielded positive results. Conversely, patients were deemed to have experienced sample "contamination" if less than two samples yielded positive results. The utilization of Kaplan-Meier curves was employed in order to visually represent the duration of time required for cultures to yield positive test results.

 Results

The cases included 60 C. acnes infections and 44 contaminations. Compared to 54.8% in the contamination cohort, 71.8% in the infection cohort utilized perioperative prophylaxis. In the cohort of infected individuals, the mean time to positive results was 7.06 days for perioperative prophylaxis and 7.09 days for patients without it. Sample positivity did not affect perioperative prophylactic usage, which was 70.6% and 64.9%.

 Conclusion

The administration of perioperative prophylaxis did not exhibit any deleterious impact on the microbiological yield observed in C. acnes infections. Henceforth, the implementation of regular antibiotic prophylaxis is deemed a safe and effective measure in the prevention of surgical site infections.

 Recommendation

It appears that perioperative preventative antibiotics for bone and joint Cutibacterium acnes infections are safe and effective. Continue antibiotic prophylaxis to prevent surgery site infections without compromising microbiological samples. Further study can establish when to provide antibiotics to improve efficacy and diagnosis.