Health system factors influencing TB drug adherence among patients aged 15 to 35 years attending health services at Entebbe regional referral hospital, Wakiso district. A cross-sectional study.
DOI:
https://doi.org/10.51168/sjhrafrica.v7i3.2434Keywords:
Anti-TB drug, Tuberculosis, TB treatment adherence, socio-demographic factors, health system factors, patient-related factorsAbstract
Background:
The study aimed to assess socio-demographic factors and explore health system-related factors influencing drug adherence among TB patients aged 15 to 35 years attending health services at Entebbe regional referral hospital, Wakiso district.
Methodology:
This study employed a descriptive cross-sectional quantitative design. A sample of 50 participants was determined using Barton’s formula and selected through simple random sampling over a 10-day period, with five respondents recruited daily. Data were collected using pretested semi-structured questionnaires administered by the researcher in both English and Luganda. Data were analyzed manually using tally sheets and Microsoft Excel to generate frequencies and charts. Ethical approval was obtained, informed consent secured, and confidentiality strictly maintained throughout the study.
Results:
Out of 50 participants, 45 were enrolled, yielding a 90% response rate. The mean age was 30 years, with most respondents aged 31 to 35 years (44.44%), followed by 26 to 30 years (26.67%), 21 to 25 years (17.78%), and 15 to 20 years (11.11%). Regarding health system factors, 55.56% traveled from distant islands of Buvuma and Kalangala, 28.89% from Entebbe and Mpigi districts, and 15.55% lived near the hospital. Missed appointments were reported by 77.78%, attributed to long waiting times, poor communication, rudeness of health workers, and drug stockouts. Among those missing refills, 85.71% used herbal remedies. Only 10 respondents received follow-up calls or counseling, while 35 (77.78%) reported no guidance, follow-up sputum testing, or support on drug adherence.
Conclusion:
Poor TB drug adherence was associated with socio-economic, social, and health system challenges.
Recommendation:
Communities should provide social support and encouragement to TB patients throughout their treatment period to improve adherence.
References
Anenmose Maro, R., Mtenga, A., Mtesha, B., Wilhelm, K., Lekashingo, N., Sumari-de Boer, M., & Ngowi, K. (2024). Implementation bottlenecks of real-time medication monitoring (evriMED) for improving adherence to anti-TB drugs among people with tuberculosis in Kilimanjaro, Tanzania. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 34, 100409. https://doi.org/10.1016/j.jctube.2023.100409
Dormechele, W., Bonsu, E. O., Boadi, C., Adams, M. O., Hlormenu, B. A., Addo, S. K., Bossman, B. B., & Addo, I. Y. (2024). Determinants of intention to conceal tuberculosis status among family members: An analysis of seven Sub-Saharan African countries. BMC Infectious Diseases, 24(1), 175. https://doi.org/10.1186/s12879-024-09064-y
Jhaveri, T. A., Jhaveri, D., Galivanche, A., Lubeck-Schricker, M., Voehler, D., Chung, M., Thekkur, P., Chadha, V., Nathavitharana, R., Kumar, A. M. V., Shewade, H. D., Powers, K., Mayer, K. H., Haberer, J. E., Bain, P., Pai, M., Satyanarayana, S., & Subbaraman, R. (2024). Barriers to engagement in the care cascade for tuberculosis disease in India: A systematic review of quantitative studies. PLOS Medicine, 21(5), e1004409. https://doi.org/10.1371/journal.pmed.1004409
Kadia, B. M., Dimala, C. A., Fongwen, N. T., & Smith, A. D. (2021). Barriers to and enablers of uptake of antiretroviral therapy in integrated HIV and tuberculosis treatment programmes in sub-Saharan Africa: A systematic review and meta-analysis. AIDS Research and Therapy, 18(1), 85. https://doi.org/10.1186/s12981-021-00395-3
Kirubi, B., Ong’ang’o, J., Nguhiu, P., Lönnroth, K., Rono, A., & Sidney-Annerstedt, K. (2021). Determinants of household catastrophic costs for drug-sensitive tuberculosis patients in Kenya. Infectious Diseases of Poverty, 10(1), 95. https://doi.org/10.1186/s40249-021-00879-4
Kılıç, A., Zhou, X., Moon, Z., Hamada, Y., Duong, T., Layton, C., Jhuree, S., Abubakar, I., Rangaka, M. X., & Horne, R. (2025). A systematic review exploring the role of tuberculosis stigma on test and treatment uptake for tuberculosis infection. BMC Public Health, 25(1), 628. https://doi.org/10.1186/s12889-024-20868-0
Matakanye, H., Tshitangano, T. G., Mabunda, J. T., & Maluleke, T. X. (2021). Knowledge, Beliefs, and Perceptions of TB and Its Treatment amongst TB Patients in the Limpopo Province, South Africa. International Journal of Environmental Research and Public Health, 18(19). https://doi.org/10.3390/ijerph181910404
Mulaku, M. N., Nyagol, B., Owino, E. J., Ochodo, E., Young, T., & Steingart, K. R. (2023). Factors contributing to pre-treatment loss to follow-up in adults with pulmonary tuberculosis: A qualitative evidence synthesis of patient and healthcare worker perspectives. Global Health Action, 16(1), 2148355. https://doi.org/10.1080/16549716.2022.2148355
Mumbe, J. M., Nzioki, J. M., Mutai, J., & Ndiritu, A. K. (2020). Socio-Demographic and Economic Factors Influencing Adherence to TB Treatment in Mwingi East Sub-County, Kitui County, Kenya. African Journal of Health Sciences, 33(6).
Nidoi, J., Muttamba, W., Walusimbi, S., Imoko, J. F., Lochoro, P., Ictho, J., Mugenyi, L., Sekibira, R., Turyahabwe, S., Byaruhanga, R., Putoto, G., Villa, S., Raviglione, M. C., & Kirenga, B. (2021). Impact of socio-economic factors on Tuberculosis treatment outcomes in north-eastern Uganda: A mixed methods study. BMC Public Health, 21(1), 2167. https://doi.org/10.1186/s12889-021-12056-1
Ochieng, M., Nyaberi, J., Mambo, S., & Wafula, C. (2024). Healthcare Worker-Related Factors Contributing to Tuberculosis Treatment Non-Adherence among Patients in Kisumu East Sub-County. Journal of Tuberculosis Research, 12(1). https://doi.org/10.4236/jtr.2024.121002
Ooms, G. I., van Oirschot, J., de Kant, D., van den Ham, H. A., Mantel-Teeuwisse, A. K., & Reed, T. (2023). Barriers to accessing internationally controlled essential medicines in sub-Saharan Africa: A scoping review. International Journal of Drug Policy, 118, 104078. https://doi.org/10.1016/j.drugpo.2023.104078
Reddy, S. C., Gijith Mohan, K. M., & Jain, K. (2025). Chapter 16—Impact of socioeconomic factors on the treatment of tuberculosis. In Emerging Paradigms in Delivery Systems for Antitubercular Therapy (pp. 353–369). Academic Press. https://doi.org/10.1016/B978-0-443-24035-5.00016-5
Shinde, A. M. (2024). Socio-demographic factors & adherence of newly diagnosed pulmonary tuberculosis patients to the newly introduced daily regimen: A hospital survey-based follow-up study. Indian Journal of Tuberculosis, 71, S250–S257. https://doi.org/10.1016/j.ijtb.2024.03.011
Tukamuhebwa, P. M., Munyewende, P., Tumwesigye, N. M., Nabirye, J., & Ndlovu, N. (2024). Health worker perspectives on barriers and facilitators of tuberculosis investigation coverage among index case contacts in rural Southwestern Uganda: A qualitative study. BMC Infectious Diseases, 24, 867. https://doi.org/10.1186/s12879-024-09798-9
VidyaRaj, C. K., Vadakunnel, M. J., Mani, B. R., Anbazhagi, M., Pradhabane, G., Venkateswari, R., Palavesam, S., Venkatesh, K., Usharani, B., Sriramkumar, S. R., Subramani, S., Govindarajan, S., & Muthuraj, M. (2025). Prevalence of extrapulmonary tuberculosis and factors influencing successful treatment outcomes among notified cases in South India. Scientific Reports, 15(1), 8290. https://doi.org/10.1038/s41598-025-92613-5
Zaidi, I., Sarma, P. S., Khayyam, K. U., Toufique Ahmad, Q., Ramankutty, V., & Singh, G. (2024). Sociodemographic factors affecting knowledge levels of tuberculosis patients in New Delhi. Journal of Family Medicine and Primary Care, 13(11), 5152–5158. https://doi.org/10.4103/jfmpc.jfmpc_387_24
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Perpetua Nabayigga , Tobius Mutabazi, Hasifah Nansereko, Franscisco Ssemuwemba, Jane Frank Nalubega

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
















