Association of serum ferritin and hematoma volume with neurological outcome in patients of deep supratentorial spontaneous intracranial haemorrhage.

Aniruddh  Shrivastava; Deepak  Goel; Ashwani  Bhat

doi:10.51168/sjhrafrica.v6i5.1993

Authors

Aniruddh Shrivastava DM Neurology Resident, Department of Neurology, HIMS, Dehradun, India
Deepak Goel MD (Medicine, DM (Neurology), Department of Neurology, HIMS, Dehradun, India
Ashwani Bhat MD (Medicine, DM (Neurology), Department of Neurology, HIMS, Dehradun, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i5.1993

Keywords:

Serum ferritin, Hematoma volume, Intracerebral hemorrhage (ICH), Neurological outcome

Abstract

Background

Deep supratentorial spontaneous intracerebral hemorrhage (ICH) is a life-threatening neurological emergency with high morbidity. Identifying reliable prognostic markers is vital for early clinical decision-making. Serum ferritin, an acute-phase reactant, and hematoma volume have been suggested as potential indicators of ICH severity and outcome.

Objectives: To assess the association between serum ferritin and hematoma volume with neurological outcomes in patients with deep supratentorial spontaneous ICH.

Methods

A retrospective observational study was conducted on 80 patients diagnosed with deep supratentorial ICH at a tertiary care hospital in Dehradun. Serum ferritin levels were measured using ELFA within 72 hours of symptom onset. Hematoma volume was calculated via CT using the ellipsoid formula. Outcomes were assessed using the modified Rankin Scale (mRS).

Results

Patients with elevated serum ferritin had significantly worse neurological outcomes (100% poor outcome, p<0.001). Similarly, larger hematoma volumes were associated with increased rates of poor outcome, especially in the very high-volume group (87.5% poor outcome). High GCS scores correlated with better outcomes.

Conclusion

Both elevated serum ferritin and larger hematoma volumes are strongly associated with poor neurological outcomes in deep supratentorial ICH, highlighting their prognostic significance in clinical management.

Recommendations
Routine assessment of serum ferritin and hematoma volume at admission should be considered in all patients with deep supratentorial ICH to aid early prognostication. Integration of these parameters into clinical risk models can improve outcome prediction and guide therapeutic decisions. Future prospective multicentric studies are recommended

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