MUCIN PROFILE OF PROSTATIC LESIONS: A HISTOCHEMICAL APPROACH FOR DIFFERENTIATION IN A TERTIARY CARE CENTER.

Dr. Srikanth.K; Dr. Vijay David  Raj; Dr. Natarajan  Suresh; Dr. Mourouguessine  Vimal

doi:10.51168/sjhrafrica.v6i3.1713

Authors

Dr. Srikanth.K Assistant Professor, Panimalar Medical College Hospital & Research Institute.
Dr. Vijay David Raj Assistant Professor, Panimalar Medical College Hospital & Research Institute.
Dr. Natarajan Suresh Professor, Sri Balaji Medical College and Hospital
Dr. Mourouguessine Vimal Professor, Sri Manakula Vinayagar Medical College & Hospital.

DOI:

https://doi.org/10.51168/sjhrafrica.v6i3.1713

Keywords:

Prostate, Mucin, PAS, Alcian Blue, Mucicarmine, Histochemistry, Benign Prostatic Hyperplasia, Adenocarcinoma

Abstract

Background: Microscopic differentiation of benign and low grade malignant lesions of prostate pose a challenging task for the pathologists. Immunohistochemistry markers can prove costlier in resource poor settings.

Objectives : To assess the utility of mucin stains in evaluating and differentiating benign and malignant lesions of prostate.

Materials and Methods : 100 prostatic biopsies received in the Pathology department of atertiary care hospital over a period of one and half years were included in this study. In additiontoroutineH&E,thesectionswerestainedwithPeriodicacidSchiff (PAS),Alcianblue(AB) andMucicarmine(MC) stains.

Results: Out of 100 prostatic biopsies studied, 90% of benign cases and 53% malignant lesions showed positivity with Periodic acid Schiff (PAS) stain. With Alcian blue, 67% of malignant lesions showed positivity and with Mucicarmine 60% of malignant lesions showed positivity. In contrast only 1% of benign lesions were positive with Alcian blue and Mucicarmine

Conclusions: Neutral mucin was found to be more frequently positive in benign lesions of prostate whereas acidic mucin is expressed only in malignant lesions