ELEVATED CIRCULATING ENDOTHELIN-1 AND OXIDATIVE STRESS AS POTENTIAL BIOMARKERS FOR PREECLAMPSIA IN WOMEN FROM TAMILNADU: A CASE CONTROL STUDY.

Authors

  • Dr. P. Bagavathiammal Associate Professor, Department of Biochemistry, Swamy Vivekanandha Medical College Hospital and Research Institute, Tiruchengode, Namakkal, Tamilnadu India.
  • Dr. P. M. Sasikala Assistant Professor, Department of Biochemistry, Government Karur Medical College, Karur, Tamilnadu India.
  • Dr. R.Menaha Assistant Professor, Department of Biochemistry, KAPV Government Medical College, Trichy, Tamilnadu India.
  • Dr. Revathi. A Assistant professor, Department of Obstetrics and Gynaecology, Government Erode Medical College Hospital, Perundurai, Erode, Tamilnadu, India.
  • Panneerselvam Periasamy Department of Physiology, Government Erode Medical College, Perundurai, Tamil Nadu, India
  • Dr. Sasikala Gunasekaran Department of Nursing, Government Erode Medical College Hospital, Perundurai, Tamil Nadu, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i3.1693

Keywords:

Preeclampsia, Endothelin-1, Oxidative Stress, Biomarkers, Pregnancy

Abstract

Background

Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by endothelial dysfunction and oxidative stress, contributing to maternal and fetal morbidity. Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of PE.

Objective:

This study aimed to evaluate ET-1 and oxidative stress markers as potential biomarkers for preeclampsia in pregnant women from Erode, Tamil Nadu.

Methods

A prospective case-control study was conducted at Government Erode Medical College Hospital, involving 86 pregnant women. Participants were categorized into preeclamptic cases (n = 46) and normotensive controls (n = 40). Serum levels of ET-1, total oxidative status (TOS), total antioxidative status (TAS), and oxidative stress index (OSI) were measured. Independent t-tests and Pearson’s correlation were performed to evaluate group differences and associations.

Results

The preeclamptic group had significantly elevated ET-1 (1.39 ± 1.31 pg/ml vs. 1.27 ± 0.285 pg/ml, p = 0.023), higher TOS (119.44 ± 6.48 µmol/L vs. 112.88 ± 3.23 µmol/L, p = 0.034), lower TAS (1.04 ± 0.259 mmol/L vs. 1.47 ± 0.388 mmol/L, p = 0.001), and higher OSI (1.44 ± 1.29 vs. 0.867 ± 0.421, p < 0.001). Demographic variables such as mean age (24.01 ± 3.43 vs. 22.64 ± 2.16 years), gravidity, and gestational age (33.1 ± 4 vs. 32 ± 4.3 weeks) showed no significant differences, confirming matched groups. Pearson’s correlation revealed a weak, non-significant association between ET-1 and OSI.

 Conclusion

Preeclampsia is associated with elevated oxidative stress and ET-1 levels, supporting their role as potential biomarkers. These findings may aid in early diagnosis and improved clinical monitoring of PE.

Recommendations

Future multi-center studies with larger cohorts and longitudinal follow-up are recommended to confirm these findings, explore causal mechanisms, and evaluate the utility of ET-1 and oxidative stress markers for risk stratification and therapeutic interventions in high-risk pregnancies.

Author Biographies

Dr. P. Bagavathiammal, Associate Professor, Department of Biochemistry, Swamy Vivekanandha Medical College Hospital and Research Institute, Tiruchengode, Namakkal, Tamilnadu India.

Dr. P. Bagavathiammal, MBBS, MD (Biochemistry), is an Associate Professor in the Department of Biochemistry at Swamy Vivekanandha Medical College Hospital and Research Institute, Tiruchengode, Namakkal, Tamil Nadu, India. She completed her MBBS from Madurai Medical College, Madurai, and obtained her MD in Biochemistry from the prestigious Madras Medical College, Chennai. With registration under the Tamil Nadu Medical Council (No. 49483),

Dr. Bagavathiammal has contributed extensively to clinical biochemistry education and research. Her academic interests include the study of biochemical markers in disease diagnostics and the integration of laboratory findings with clinical decision-making. ORCID ID: https://orcid.org/0009-0008-3362-9506

 

Dr. P. M. Sasikala, Assistant Professor, Department of Biochemistry, Government Karur Medical College, Karur, Tamilnadu India.

Dr. P. M. Sasikala, M.D. (Biochemistry) is an accomplished medical educator and researcher, currently serving as an Assistant Professor in the Department of Biochemistry at Government Karur Medical College, Karur, Tamil Nadu, India. With a strong academic foundation and clinical insight, she brings a deep understanding of biochemical principles and their applications in medical science.

Dr. Sasikala holds an M.D. in Biochemistry and has been actively involved in teaching, curriculum development, and mentoring undergraduate medical students. Her academic interests span clinical biochemistry, molecular biology, and metabolic disorders, and she is committed to integrating evidence-based teaching methodologies to enhance learning outcomes.

As a researcher, she has contributed to the advancement of medical biochemistry through publications and collaborative projects, focusing on the biochemical basis of diseases and their diagnostic and therapeutic implications. Her dedication to academic excellence and scientific inquiry continues to inspire both students and peers alike.

With her passion for education and research, Dr. Sasikala plays a vital role in shaping future healthcare professionals and advancing the field of medical biochemistry. ORCID ID: https://orcid.org/0000-0001-8050-0491

Dr. R.Menaha, Assistant Professor, Department of Biochemistry, KAPV Government Medical College, Trichy, Tamilnadu India.

Dr. R. Menaha, MD (Biochemistry), is an Assistant Professor in the Department of Biochemistry at KAPV Government Medical College, Trichy, Tamil Nadu, India. She earned her MBBS from Government Madurai Medical College, Madurai, and completed her MD in Biochemistry from Dhanalakshmi Srinivasan Medical College, Siruvachur, Perambalur. With over four years of teaching experience, she has actively mentored undergraduate students in research and academic endeavors. Dr. Menaha has authored three research publications in reputed journals, with a focus on clinical biochemistry and public health. ORCID ID: https://orcid.org/0000-0003-2235-0530

Dr. Revathi. A, Assistant professor, Department of Obstetrics and Gynaecology, Government Erode Medical College Hospital, Perundurai, Erode, Tamilnadu, India.

Dr. A. Revathi, MS (Obstetrics and Gynaecology), is currently serving as Assistant Professor in the Department of Obstetrics and Gynaecology at Government Erode Medical College Hospital, Perundurai, Erode, Tamil Nadu, India. She completed her MBBS from Government Vellore Medical College, Vellore, and pursued her MS in Obstetrics and Gynaecology at Theni Government Medical College, Theni. She is registered with the Tamil Nadu Medical Council (Reg. No. 93373) and is dedicated to women’s health, clinical teaching, and maternal care in the public healthcare system. She is dedicated to both clinical practice and medical education, contributing to the academic and professional growth of undergraduate and postgraduate students. Her areas of interest include maternal health, reproductive medicine, and women’s wellness. She is actively involved in patient care, teaching, and collaborative research. ORCID ID:https://orcid.org/0009-0008-4375-8926

Panneerselvam Periasamy , Department of Physiology, Government Erode Medical College, Perundurai, Tamil Nadu, India

Dr. P. Panneerselvam, Ph.D, is a seasoned academician and researcher with over two decades of experience in medical physiology. He currently serves as an Associate Professor in the Department of Physiology at Government Erode Medical College, Perundurai, Tamil Nadu, India. Dr. Panneerselvam holds a Ph.D. in Medical Physiology from Vinayaka Missions Research Foundation (VMRF), Salem, an M.Sc. in Medical Physiology from Kasturba Medical College, MAHE, Manipal, and an M.A. in Yoga for Human Excellence from Bharathiar University.

He has published over 90 original research papers in various national and international peer-reviewed journals. His doctoral research focused on the effects of Simplified Kundalini Yoga (SKY) practices on physiological, psychological, hematological, and hormonal parameters in moderately stressed students.

Dr. Panneerselvam has actively contributed to the academic and administrative development of his institution, serving as a nodal officer for NMC and university-related initiatives, and as a member of several institutional committees including NABH and HIMS. He is also a dedicated mentor and faculty trainer, involved in numerous workshops, conferences, and faculty development programs related to physiology, research methodology, medical education, and yoga.

His current research interests include the impact of yoga on mental health and well-being, physiological stress responses, and integrative approaches to medical education and student wellness. ORCID ID: https://orcid.org/0000-0002-3358-313X

 

Dr. Sasikala Gunasekaran, Department of Nursing, Government Erode Medical College Hospital, Perundurai, Tamil Nadu, India

Dr. G. Sasikala, Ph.D., is a distinguished academician, seasoned researcher, and dedicated healthcare leader with over two decades of excellence in nursing education, clinical practice, and scientific research. She currently serves as a Nursing Officer at Government Erode Medical College, Perundurai, where she plays a key role in delivering quality patient care, mentoring nursing students, and contributing to the institution’s healthcare administration.

Dr. Sasikala earned her Ph.D. in Psychiatric Nursing from Vinayaka Missions Research Foundation, following her M.Sc. in Psychiatric Nursing from Matha College of Nursing, Manamadurai, and a B.Sc. in Nursing from Madras Medical College. She also holds an M.A. in Yoga for Human Excellence from Bharathiar University, Coimbatore, highlighting her commitment to holistic health approaches.

With over 50 original research publications in esteemed national and international journals, her scholarly contributions span mental health, psychiatric nursing, holistic patient care, and the integration of yoga into clinical nursing practices. She has successfully led several research initiatives and scientific innovations that have enriched evidence-based nursing and improved patient outcomes.  ORCID ID: https://orcid.org/0000-0003-4986-6588

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Published

2025-03-31

How to Cite

P.Bagavathiammal, P. M. Sasikala, R.Menaha, Revathi.A, Periasamy , P. ., & Gunasekaran, D. S. (2025). ELEVATED CIRCULATING ENDOTHELIN-1 AND OXIDATIVE STRESS AS POTENTIAL BIOMARKERS FOR PREECLAMPSIA IN WOMEN FROM TAMILNADU: A CASE CONTROL STUDY. Student’s Journal of Health Research Africa, 6(3), 9. https://doi.org/10.51168/sjhrafrica.v6i3.1693

Issue

Vol. 6 No. 3 (2025): March 2025 Issue

Section

Section of Biochemistry

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Copyright (c) 2025 Dr. P. Bagavathiammal, Dr. P. M. Sasikala, Dr. R.Menaha, Dr. Revathi. A, Panneerselvam Periasamy , Dr. Sasikala Gunasekaran

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