A SYSTEMATIC EVALUATION AND ECONOMIC ASSESSMENT OF SUGAMMADEX IN GENERAL ANAESTHESIA FOR MUSCLE RELAXATION REVERSAL: A PROSPECTIVE CROSS-SECTIONAL STUDY.

Piyush Kumar  Sengar; Mrituanjay  Kumar

doi:10.51168/sjhrafrica.v5i3.1148

Authors

Piyush Kumar Sengar Assistant Professor, Department of Anaesthesia, SNNMCH, Dhanbad, Jharkhand, India
Mrituanjay Kumar Assistant Professor, Department of Anaesthesia, SNNMCH, Dhanbad, Jharkhand, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i3.1148

Keywords:

Operative laryngoscopy, Intravenous Anaesthesia, Neostigmine, Sugammadex

Abstract

Introduction

An ambulatory treatment that is frequently used on patients who have high co-morbidity is operative laryngoscopy. Utilizing the surgical exposure best anaesthetics and returning to baseline as soon as possible after surgery improves postoperative patient safety.

Aim

To find out if sugammadex speeds up healing in patients who are having operational laryngoscopy while under general anaesthesia and have paralysis from rocuronium.

Methods

The total of 168 participants were randomly assigned to the two groups. Both groups were given inhaled anaesthetics consisting of remifentanil, sevoflurane, and rocuronium at 0.6 to 1.2 mg/kilogram doses for intubation and preventing nausea. Neostigmine (0.04 mg per kilogram) and glycopyrrolate (0.01 mg/kg) were administered as a reversal to Group 1. Group 2 was given sugammadex (4 mg/kg) as a reversal. In both groups, vital markers were kept at a baseline of 20%. The duration required for extubation after the operations was the primary outcome measure.

Results

There were 168 people, and the age, sex, and weight distributions in the groups were comparable. The time needed to fulfil the discharge conditions was the only difference between the two groups' primary and secondary outcomes such as consciousness level, physical mobility, pain control, and possibly other vital signs. There was no significant difference in the extubation times between the two groups. However, a higher proportion of patients in the Sugammadex group (65%) achieved an Aldrete score of 18 or higher upon compared to the Neostigmine group (35%), indicating a faster readiness for discharge.

Conclusion

Enhancing the anaesthetic regimen, maintaining steady intraoperative hemodynamics, and using sugammadex for reversal all contribute to patients who are more prepared for discharge following surgical laryngoscopy.

Recommendation

It is recommended determining if there is any prior complication or side-effect related to administer sugammadex or neostigmine in patients to rule out any further complication.