Prevalence of elevated alanine aminotransferase levels among HIV patients on HAART in Naguru Hospital in Kampala District. A cross-sectional study.
DOI:
https://doi.org/10.51168/sjhrafrica.v7i3.2306Keywords:
Alanine aminotransferase, Elevated ALT levels, fatty liver disease, Liver function, Prevalence, Naguru HospitalAbstract
Background:
The study aimed to determine the prevalence of elevated ALT levels among HIV patients on HAART in Naguru Hospital in Kampala District.
Methodology:
The study utilized a cross-sectional design involving participants attending HIV care clinics. Data were collected through patient records, interviews, and laboratory investigations, including liver function tests and metabolic assessments. The prevalence of liver diseases and treatment-related adverse effects was determined. Statistical analysis was conducted to explore relationships between variables. Ethical considerations were observed by obtaining approval from relevant authorities and informed consent from participants, ensuring confidentiality and voluntary participation throughout the research process.
Results:
A total of 88 participants were included. The prevalence of elevated alanine aminotransferase (ALT) levels among participants was 46.6% (41/88), while 53.4% (47/88) had normal ALT levels. Out of the total participants, 56 (63.6%) were female, while 32 (36.4%) were male, indicating that the majority of participants were female. With regard to place of residence, the majority of respondents lived in urban areas (60, 68.2%), whereas 28 (31.8%) resided in rural areas. Most respondents were single (58, 65.9%), while 20 (22.7%) were married. A smaller proportion were divorced (8, 9.1%), and 2 (2.3%) were widowed.
Conclusion:
The study found a relatively high prevalence of elevated alanine aminotransferase (ALT) levels.
Recommendation:
More improved HAART drugs with less toxicity should be introduced to HIV patients to curb the increasing prevalence of elevated ALT levels.
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Copyright (c) 2026 Hillary Kasadha , Anthony Isaiah Ssekitoleko, Hasifa Nansereko, Fransisco Semuwemba, Jane Frank Nalubega
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