Health facility factors influencing utilization of premarital sickle cell trait screening services among the youth attending Entebbe regional referral hospital, Wakiso district. A cross-sectional study.
DOI:
https://doi.org/10.51168/sjhrafrica.v7i3.2282Keywords:
Premarital Screening, Sickle Cell Trait, Health Facility Accessibility, Screening UptakeAbstract
Background
The study aims to assess the health facility factors influencing uptake of premarital sickle cell trait screening services.
Methodology
A descriptive cross-sectional study using quantitative methods was conducted among 40 youths aged 18 years and above. Convenience sampling was employed. Data were collected using structured and semi-structured questionnaires, checked for completeness, coded, and analyzed using Microsoft Excel. Findings were presented using frequencies, percentages, tables, and figures.
Results
33 (82.5%) of the respondents were unemployed, and 7 (17.5%) were employed. The majority, 36 (90%), had never received counselling about premarital sickle cell trait screening, and 4 (10%) had received counselling. 23 (57.5%) lived 3–5 km away from the facility, while the least 5 (12.5%) lived below 2 km. Concerning the availability of equipment, 37 (92.5%) did not know about the equipment, while at least 1 (2.5%) reported that it was not available. During other care, the majority, 35 (87.5%), were not educated about sickle cell trait screening, whereas at least 5 (12.5%) were educated. The majority (72.5%) of the respondents mentioned a few facilities offering sickle cell trait screening service as a factor influencing their uptake, while (12.5%) cited lack of reagents.
Conclusion
Health facility factors like long distances, few screening centers, and limited outreach influenced the uptake of premarital sickle cell trait screening.
Recommendation
Health Facilities should increase accessibility by establishing more centers that offer premarital sickle cell trait screening services, including outreach services for remote areas.
References
Abioye-Kuteyi, E. A., Osakwe, C., Oyegbade, O., & Bello, I. (2019). Sickle cell knowledge, premarital screening and marital decisions among local government workers in Ile-Ife, Nigeria. African Journal of Primary Health Care and Family Medicine, 1(1), 1-5.
Adesina, O. A., Ogamba, C. F., & Osibogun, A. (2022). Premarital Genotype Screening for Sickle Cell Disease: Knowledge Gaps, Perception and Determinants of Uptake among Final Year Undergraduates of a Tertiary Institution in South-West Nigeria. Nigerian medical journal: journal of the Nigeria Medical Association, 63(1), 50–58. https://doi.org/10.60787/NMJ-63-1-94
Adeyemo, O. A., Omidiji, O. O., & Shabi, O. A. (2017). Level of awareness of genetic counselling in Lagos, Nigeria: its advocacy on the inheritance of sickle cell disease. African Journal of Biotechnology, 6(24).
Adigwe, O. P., Onoja, S. O., & Onavbavba, G. (2023). A Critical Review of Sickle Cell Disease Burden and Challenges in Sub-Saharan Africa. Journal of blood medicine, 14, 367–376. https://doi.org/10.2147/JBM.S406196
Agbozo, W. K., Amanor, E., Acheampong, E. O., Kotei, B., Attoh, L. N., Yeboah, D., Odonkor, P., Obiri, S., Kwarteng, A., & Larbi, A. (2023). Assessing knowledge of sickle cell disease and health beliefs on premarital genetic screening among healthcare trainees at a tertiary institution: A cross-sectional study. Health science reports, 6(2), e1128. https://doi.org/10.1002/hsr2.1128
Al-Shafai, M., Al-Romaihi, A., Al-Hajri, N., Islam, N., & Adawi, K. (2022). Knowledge and Perception of and Attitude toward a Premarital Screening Program in Qatar: A Cross-Sectional Study. International journal of environmental research and public health, 19(7), 4418. https://doi.org/10.3390/ijerph19074418
Alzahrani, S. S. J., Alghamdi, N. S. A., Alzahrani, E. A. M., Alzahrani, F. A. M., Alghamdi, M. A. A., Hafiz, Z. M. S., & Fouad, A. A. (2024). Knowledge of Sickle Cell Disease Among Medical Students at Al-Baha University, Saudi Arabia: A Cross-Sectional Study. Cureus, 16(1).
Ashorobi, D., Ramsey, A., Killeen, R. B., & Bhatt, R. (2024). Sickle cell trait. In StatPearls [Internet]. StatPearls Publishing.
Beli, I. I., Ali, L. A., Onuoha, C. C., Jasseh, M., Zentar, M., Belakoul, N., ... & Umar, M. (2024). Socio-economic burden of sickle cell disease on families attending sickle cell clinic in Kano state, northwestern Nigeria. Global Pediatrics, 9, 100193.
Dilli, P. P., Obeagu, E., Tamale, A., Pius, T., & Makeri, D. (2025). Low uptake and poor knowledge of preconception sickle cell trait screening among pregnant women in Bushenyi District, southwestern Uganda: Implications for sustainable development goals. Preventive medicine reports, 54, 103106. https://doi.org/10.1016/j.pmedr.2025.103106
Ezugwu, E. C., Osamor, P. E., & Wendler, D. (2019). Ethical issues in denial of church wedding based on couple’s hemoglobin genotype in Enugu, south eastern Nigeria. BMC Medical Ethics, 20, 1-7.
Houwing, M. E., De Pagter, P. J., Van Beers, E. J., Biemond, B. J., Rettenbacher, E., Rijneveld, A. W., ... & SCORE Consortium. (2019). Sickle cell disease: clinical presentation and management of a global health challenge. Blood reviews, 37, 100580.
Isah, B. A., Musa, Y., Mohammed, U. K., Ibrahim, M. T. O., Awosan, K. J., & Yunusa, E. U. (2016). Knowledge and attitude regarding premarital screening for sickle cell disease among students of State school of nursing Sokoto. Ann Int Med Dent Res, 2(3), 29-34.
Kisakye, E., Gavamukulya, Y., & Barugahare, B. J. (2022). Sickle cell trait screening in students in a Ugandan university: a cross-sectional study. The Journal of international medical research, 50(11), 3000605221138491. https://doi.org/10.1177/03000605221138491
Kyakuha, S., Scovia, M. G., Mugenyi, N., & Twineamatsiko, A. (2024). Factors associated with utilization of preconception Sickle cell screening among women receiving antenatal care at Hoima regional referral hospital, Uganda. medRxiv, 2024-05.
Namukasa, S., Maina, R., Nakaziba, S., Among, G., Asasira, L., Mayambala, P., Atukwatse, J., Namuguzi, M., & Sarki, A. M. (2024). Prevalence of sickle cell trait and needs assessment for uptake of sickle cell screening among secondary school students in Kampala City, Uganda. PloS one, 19(1), e0296119. https://doi.org/10.1371/journal.pone.0296119
Namukasa, S., Maina, R., Nakaziba, S., Among, G., Asasira, L., Mayambala, P., Atukwatse, J., Namuguzi, M., & Sarki, A. M. (2024). Prevalence of sickle cell trait and needs assessment for uptake of sickle cell screening among secondary school students in Kampala City, Uganda. PloS one, 19(1), e0296119. https://doi.org/10.1371/journal.pone.0296119
Ndaigeze, I., Kabalimu, T., & Ntabaye, M. (2025). Determinants of perception and willingness to uptake premarital screening test for sickle cell disease among health sciences undergraduate students in Dar es Salaam, Tanzania. Journal of Community Genetics, 1-9.
Obeagu, Dilli, P. P., E., Tamale, A., Ajugwo, A., Pius, T., & Makeri, D. (2024). Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis. BMC public health, 24(1), 1467. https://doi.org/10.1186/s12889-024-19001-y
Okwi, A. L., Byarugaba, W., Ndugwa, C. M., Parkes, A., Ocaido, M., & Tumwine, J. K. (2020). An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda. BMC Hematology, 10(1), 5.
Oluwole, E. O., Okoye, C. D., Ogunyemi, A. O., Olowoselu, O. F., & Oyedeji, O. A. (2022). Knowledge, attitude and premarital screening practices for sickle cell disease among young unmarried adults in an urban community in Lagos, Nigeria. The Pan African medical journal, 42, 8. https://doi.org/10.11604/pamj.2022.42.8.27705
Orelaru, F., Bolanle, G., Tolulope, I., & Ishmael, J. (2019). Assessing knowledge of sickle cell trait/disease inheritance in metropolitan Detroit. Journal of the National Medical Association, 111(6), 656-664.
Pecker, L. H., & Naik, R. P. (2018). The current state of sickle cell trait: implications for reproductive and genetic counseling. Hematology. American Society of Hematology. Education Program, 2018(1), 474–481. https://doi.org/10.1182/asheducation-2018.1.474
Rasheed, T. O., Afolabi, W. A., Rasheed, R. O. A., & Ajala, R. A. (2018). Premarital sickle cell genetic screening knowledge, attitude and practice compared among married and unmarried youths in Nigeria. World J Public Health, 3(3), 76-82.
Sarpong, M. L., Tetteh, R. J., Amponsah, F. A., Amo-Kodieh, P., Owusu, E. A., Ntiamoah, P., .& Kuupiel, D. (2025). Young adults’ knowledge, attitudes, and practices regarding premarital screening for genetic blood disorders and associated sociodemographic determinants in the Ahafo Region of Ghana: a cross-sectional study. Archives of Public Health, 83(1), 128.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Nicholas Mujulizi Ahebwa, George Masete, Hasifa Nansereko, Immaculate Naggulu, Jane Frank Nalubega

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
















