THE CLINICAL RELEVANCE OF INTERLEUKIN 6 & hs-CRP IN CARDIOVASCULAR DISEASES:  A CASE STUDY.

Randhir  Kumar; Rakesh  Kumar; Shaily  Shilpa; Shailesh  Kumar; Samir  Kumar; Sweta  Muni; Namrata  Kumari

doi:10.51168/sjhrafrica.v6i3.1645

Authors

Randhir Kumar Associate Professor, Department of Microbiology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India
Rakesh Kumar Additional Professor, Department of Microbiology,Indira Gandhi Institute of Medical Science,Patna,Bihar,India.
Shaily Shilpa PhD Scholar, Department of Biochemistry, Indira Gandhi Institute of Medical Science,Patna,Bihar,India.
Shailesh Kumar Professor, Department of Microbiology,Indira Gandhi Institute of Medical Science,Patna,Bihar,India
Dr. Samir Kumar Associate Professor, Department of General Medicine,Indira Gandhi Institute of Medical Science,Patna,Bihar,India.
Sweta Muni Associate Professor,Department of Microbiology,Indira Gandhi Institute of Medical Science,Patna,Bihar,India.
Namrata Kumari Professor & HOD,Department of Microbiology,Indira Gandhi Institute of Medical Science,Patna,Bihar,India.

DOI:

https://doi.org/10.51168/sjhrafrica.v6i3.1645

Keywords:

Cardiovascular Disease (CVD), Lipid Profile, High-Sensitivity C-Reactive Protein (hs-CRP), Interleukin-6 (IL-6)

Abstract

Background

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, necessitating the identification of reliable biomarkers for early detection and risk assessment. Among these, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) have emerged as crucial inflammatory mediators linked to the pathogenesis and development of CVD. Pro-inflammatory cytokine IL-6 is essential in endothelial dysfunction, atherosclerosis, and plaque instability, while hs-CRP serves as a systemic marker of inflammation, correlating with vascular injury and adverse cardiac events.n. This study aims to assess the association of baseline IL-6, hs-CRP, and LDL-C levels with cardiovascular events over one year in patients undergoing intensive cardiovascular treatment.

Methods

This research consisted of 100 patients with cardiovascular disease (CVD) and 100 healthy controls. After obtaining consent, demographic data, medication history, and cardiovascular risk factors were recorded. Clinical parameters, including age, sex, height, body weight, and blood pressure, were also recorded. Patients with liver diseases, renal dysfunctions, thyroid disorders, HIV, and acute inflammatory conditions were excluded. Blood samples were obtained for biochemical examination after a 12-hour fast. IL-6 levels were quantified using an ELISA kit (Ray Biotech, Inc.), Serum hs-CRP was measured using photometric analysis (autoimmune), and lipid profiles were assessed using enzymatic and colorimetric techniques.

Results

Patients with CVD showed significantly raised levels of total cholesterol, LDL, VLDL, triglycerides, hs-CRP, and IL-6 (p<0.0001), while HDL levels were lower. Increased BMI, waist circumference, and blood pressure were also noted. These results reinforce the link between dyslipidemia, inflammation, and CVD, emphasizing their importance in disease progression and risk evaluation.

Conclusion

Elevated hs-CRP and IL-6 levels may help in the prediction of cardiovascular risks and further improve the stratification in suspected coronary artery disease (CAD) cases. Managing risk factors in high-risk patients and further research on IL-6’s causal role are essential.

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