NOVEL TREATMENT FOR FEMORAL HEAD OSTEONECROSIS USING MICRO-CORE DECOMPRESSION AND INTRALESIONAL ZOLENDRONIC ACID: A PROSPECTIVE STUDY
DOI:
https://doi.org/10.51168/sjhrafrica.v5i12.1471Keywords:
Avascular Necrosis, Micro-Core Decompression, Zolendronic acid, Harris Hip Score, Hip PreservationAbstract
Background
Avascular necrosis (AVN) of the hip often leads to joint collapse and necessitates total hip arthroplasty, especially in younger patients. Hip preservation strategies, such as core decompression, aim to delay disease progression. Combining micro-core decompression with local zoledronic infiltration is a novel approach with potential advantages.
Methods
This prospective study included 15 patients (19 hips) with AVN stages I to III, treated with micro-core decompression and local zoledronic acid infiltration. Patients were followed for two years, with outcomes assessed using Harris Hip Scores (HHS) and radiological evaluations. Data were analyzed using appropriate statistical tests.
Results
At two years, mean HHS improved significantly across all stages: 97.3 (stage I), 91.1 (stage IIa), 88.4 (stage IIb), and 82.5 (stage III). Radiological improvements included restoration of femoral head morphology and prevention of collapse progression. Postoperative complications were minimal, with two cases of superficial infection and two of trochanteric bursitis, all managed successfully.
Conclusion
Micro-core decompression combined with local zoledronic infiltration effectively improves outcomes in early to intermediate AVN, with minimal complications. This novel technique holds promise for hip preservation, particularly in younger patients.
Recommendation
Baseline screening of hip joints at diagnosis and then at regular intervals to screen the patients for any asymptomatic avascular necrosis and early treatment is recommended.
References
Baig SA, Baig MN. Osteonecrosis of the Femoral Head: Etiology, Investigations, and Management. Cureus. 2018;10(8):3171. https://doi.org/10.7759/cureus.3171
Kakaria HL, Sharma AK, Sebastian B. Total Hip Replacement in Avascular Necrosis of Femoral Head. Med J Armed Forces India. 2005;61(1):33‐5. https://doi.org/10.1016/S0377-1237(05)80115-7
Vardhan H, Tripathy SK, Sen RK, Aggarwal S, Goyal T. Epidemiological Profile of Femoral Head Osteonecrosis in the North Indian Population. Indian J Orthop. 2018;52(2):140‐6. https://doi.org/10.4103/ortho.IJOrtho_292_16
Boskey AL, Raggio CL, Bullough PG, Kinnett JG. Changes in the bone tissue lipids in persons with steroid and alcohol-induced osteonecrosis. Clin Orthop Relat Res. 1983;172:289-95. https://doi.org/10.1097/00003086-198301000-00046
Matsuo K, Hirohata T, Sugioka Y, Ikeda M, Fukuda A. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res. 1988;234:115- 23. https://doi.org/10.1097/00003086-198809000-00021
Koo KH, Kim R, Kim YS, Ahn IO, Cho SH, Song HR, et al. The risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol. 2002;21:299-303. https://doi.org/10.1007/s100670200078
Angeler MJ, Gianakos A, Villa J, Ni A, Lane J. Current concepts on osteonecrosis of the femoral head. World J Orthop. 2015; 6:590-601. https://doi.org/10.5312/wjo.v6.i8.590
Lieberman JR, Berry DJ, Mont MA, Aaron RK, Callaghan JJ, Rajadhyaksha AD, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect. 2003; 52:337-55.
Sen RK. Management of avascular necrosis of femoral head at pre-collapse stage. Indian J Orthop. 2009; 43:6-16. https://doi.org/10.4103/0019-5413.45318
Mont MA, Hungerford DS. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 1995; 77:459-74.
https://doi.org/10.2106/00004623-199503000-00018
Dayan AY, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME. Pathogenesis and natural history of osteonecrosis. Seminars Arthritis Rheumatism. 2002;32(2):94-124. https://doi.org/10.1053/sarh.2002.33724b https://doi.org/10.1053/sarh.2002.3202094
Ashraf, M., George, J., & Sha, I. I. (2021). Micro-Core decompression combined with intralesional zoledronic acid as a treatment of osteonecrosis of the femoral head: A novel technique. Journal of Orthopedics Traumatology and Rehabilitation, 13(1), 21-25. https://doi.org/10.4103/jotr.jotr_46_20
Polkowski GG, Callaghan JJ, Mont MA, Clohisy JC. Total Hip Arthroplasty in the Very Young Patient. J Am Academy Orthopaedic Surg. 2012;20(8):487-97. https://doi.org/10.5435/JAAOS-20-08-487
Arlet J, Ficat RP. Forage-biopsie de la tete femorale dans 1'osteonecrose primitive; Observations histopathologiques portant sur huit foranes. Rev Rhum Ed Fr. 1964;31:257-64.
Kim SY, Kim DH, Park IH. Multiple drilling compared with core decompression for the treatment of osteonecrosis of the femoral head. J Bone Joint Surg Br. 2004;86:149.
Song WS, Yoo JJ, Kim YM, Kim HJ. Results of Multiple Drilling Compared with Those of Conventional Methods of Core Decompression. Clin Orthopaedics Related Res. 2007;454:139-46. https://doi.org/10.1097/01.blo.0000229342.96103.73
Li J, Li ZL, Zhang H, Su XZ, Wang KT, Yang YM. Long-term Outcome of Multiple Small-diameter Drilling Decompression Combined with Hip Arthroscopy versus Drilling Alone for Early Avascular Necrosis of the Femoral Head. Chinese Med J. 2017;130(12):1435-40. https://doi.org/10.4103/0366-6999.207470
Peled E, Bejar J, Barak M, Orion E, Norman D. Core decompression and alendronate treatment of the osteonecrosis rat femoral head: computer-assisted analysis. Int J Exp Pathol. 2013;94:212-6. https://doi.org/10.1111/iep.12022
Zhang C, Zeng B, Xu Z, Song W, Shao L, Jing D, et al. Treatment of femoral head necrosis with free vascularized fibula grafting: a preliminary report. Microsurgery. 2005;25:305-9. https://doi.org/10.1002/micr.20118
Fang T, Zhang EW, Sailes FC, McGuire RA, Lineaweaver WC, Zhang F. Vascularized fibular grafts in patients with avascular necrosis of femoral head: A systematic review and meta-analysis. Arch Orthop Trauma Surg. 2013;133:1-10. https://doi.org/10.1007/s00402-012-1627-z
Agarwala S, Jain D, Joshi VR, Sule A. Efficacy of alendronate, a bisphosphonate, in the treatment of AVN of the hip: a prospective open-label study. Rheumatology. 2005;44:352-9. https://doi.org/10.1093/rheumatology/keh481 https://doi.org/10.1093/rheumatology/kei004
Agarwala S, Shah SB. Ten-year follow-up of avascular necrosis of femoral head treated with alendronate for 3 years. J Arthroplasty. 2011;26:1128-34. https://doi.org/10.1016/j.arth.2010.11.010
Nishii T, Sugano N, Miki H, Hashimoto J, Yoshikawa H. Does alendronate prevent collapse in osteonecrosis of the femoral head? Clin Orthop Relat Res. 2006;443:273-9. https://doi.org/10.1097/01.blo.0000194078.32776.31
Chen CH, Chang JK, Lai KA, Hou SM, Chang CH, Wang GJ. Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: A two-year multicenter, prospective, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2012;64:1572-8. https://doi.org/10.1002/art.33498
Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg Am. 2005;87:2155-9. https://doi.org/10.2106/JBJS.D.02959 https://doi.org/10.2106/00004623-200510000-00001
Wei, Biao, Ge, Xiang. Treatment of osteonecrosis of the femoral head with core decompression and bone grafting. Hip Int J Clin Experimental Res Hip Pathology Therapy. 2011;21:206-10. https://doi.org/10.5301/hip.2011.6525
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Kumar Rahul, Nilesh Kumar Agrawal, Mohsin Parvez, Wasim Ahmed, Indrajeet Kumar, Santosh Kumar

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.