Pregabalin vs. Duloxetine for Postoperative Analgesic Requirements Following Lower Limb Orthopaedic Surgery

Authors

  • Kritika Raj  MD Anaesthesia, Department of Anaesthesia, RIMS, Ranchi, Jharkhand, India
  • Praveen Kumar Tiwary  Associate Professor, Department of Anaesthesia, RIMS, Ranchi, Jharkhand, India
  • Mukesh Kumar Assistant Professor, Department of Anaesthesia, RIMS, Ranchi, Jharkhand, India
  • Saurabh Suman  Assistant Professor, Department of Anaesthesia, RIMS, Ranchi, Jharkhand, India,
  • Ladhu Lakra Professor, Department of Anaesthesia, RIMS, Ranchi, Jharkhand, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i6.1279

Keywords:

Pregabalin, Duloxetine, Analgesia, Comparative Study

Abstract

Background: Pregabalin and duloxetine have been used as an analgesic after lower lumbar trauma surgeries. The effectiveness of both drugs is not compared in the literature. Here the response rate of rescue is compared between both analgesics.

Method: In total, the 60 patients who underwent the lower lumbar trauma surgery were considered for this study. They were divided into two groups one of them received pregabalin 6 and the other received duloxetine. The method of surgery was similar in both groups. The response rescue rate was measured and compared. The patient’s satisfaction score, visual analogue score, total analgesia induced, and movements after the surgery were also studied.

Results: The rescue response analgesia was required in the pregabalin group after 24 hours in 60% of the patients. Whereas the duloxetine group required analgesia after 24 hours in 50% of the patients The second dose was required after 72 hours in 6.6% of the patients in the pregabalin group. In the duloxetine group second dose was required in 10% of the patients after 40 hours.

Conclusion: The dose requirement and the other parameters when compared statistically there was no significant difference obtained in the pregabalin group and duloxetine group.

Recommendation: Pregabalin and duloxetine can be used effectively in postoperative lower limb surgeries without any significant difference

Published

2024-07-02

How to Cite

Raj, K. ., Tiwary, P. K. ., Kumar, M. ., Suman, S. ., & Lakra, L. . (2024). Pregabalin vs. Duloxetine for Postoperative Analgesic Requirements Following Lower Limb Orthopaedic Surgery. Student’s Journal of Health Research Africa, 5(6). https://doi.org/10.51168/sjhrafrica.v5i6.1279

Issue

Section

Section of Anesthesia and Surgery Research