PHENOTYPES OF COPD PATIENTS WITH RESPIRATORY FAILURE AND THEIR RESULTS IN ICU SETUP: A ONE-YEAR OBSERVATIONAL STUDY.

Authors

  • Devendra Prasad Singh  Professor and Head, Department of Medicine, Angika Hospital and Research Centre, Patal Babu Road, Bhagalpur, Bihar, India
  • Rajeev Ranjan Director, Chest Hospital, Chapra, Bihar, India
  • Utkarsh Singh  Resident, Department of Pulmonary Medicine, Bharati Vidhiyapeeth Medical College, Pune, Maharashtra, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i3.1107

Keywords:

Chronic Obstructive Pulmonary Disease, Respiratory Failure, Phenotypes, Outcomes

Abstract

Background:

Airflow restriction and persistent respiratory symptoms are characteristic features of Chronic Obstructive Pulmonary Disease (COPD), a diverse disease. The intricacy of the disease is shown by the phenotypic diversity of individuals with COPD who are experiencing respiratory failure in the Intensive Care Unit (ICU). The study aimed to investigate the phenotypes of COPD patients with respiratory failure and analyze their outcomes over one year.

Methods:

An observational study was carried out enrolling 80 COPD patients admitted to the ICU due to respiratory failure. Patients aged 40 years and above with confirmed COPD diagnosis were included. Data on demographics, COPD severity, exacerbation history, comorbidities, and ICU admission details were collected. Pulmonary function tests, arterial blood gas analysis, and information on respiratory support modalities were documented. Phenotypic characterization was performed using established criteria, and outcome measures included mortality rates and ICU stay duration.

Results:

The study population was 65% male and averaged 65 years old. Patients were 40% emphysema-dominant, 30% chronic bronchitis-dominant, and 30% mixed. Emphysema-dominant patients had worse airflow limitation. Hypertension, coronary heart disease, and diabetes were frequent. Hypoxemia and hypercapnia were seen in pulmonary function tests. Mechanical breathing was needed by 70% of patients, and ICU mortality was 25%. In long-term survival study, exacerbation frequency and comorbidities significantly predicted a 40% one-year mortality rate.

Conclusion:

The study highlights the diverse phenotypes of COPD patients with respiratory failure and their associated outcomes. Personalized management strategies tailored to specific phenotypes and addressing comorbidities are crucial for improving patient outcomes. Further research is needed to refine treatment approaches and enhance long-term survival in this population.

Recommendations:

Clinicians should consider phenotypic variations and comorbidities when managing COPD patients with respiratory failure. Interventions targeting exacerbation prevention and comorbidity management may improve outcomes.

Published

2024-03-30

How to Cite

Singh, D. P. ., Ranjan, R. ., & Singh, U. . (2024). PHENOTYPES OF COPD PATIENTS WITH RESPIRATORY FAILURE AND THEIR RESULTS IN ICU SETUP: A ONE-YEAR OBSERVATIONAL STUDY. Student’s Journal of Health Research Africa, 5(3). https://doi.org/10.51168/sjhrafrica.v5i3.1107

Issue

Section

Section of General Medicine Research