COMPARING CLINICAL EFFICACY OF PROPOFOL KETAMINE COMBINATION VERSUS PROPOFOL ALONE IN AMBULATORY ANAESTHESIA: AN OBSERVATIONAL COMPARATIVE STUDY.

Soubhagya Kumar  Das; Nagendra Kumar  Rajsamant; Chittaranjan  Thatei; Satyajit  Jena

doi:10.51168/sjhrafrica.v4i12.915

Authors

Soubhagya Kumar Das Assistant Professor, Department of Anaesthesiology, SCB Medical College and Hospital, Cuttack, Odisha, India.
Nagendra Kumar Rajsamant Assistant Professor, Department of Surgery, SCB Medical College, Cuttack, Odisha, India.
Chittaranjan Thatei Assistant Professor, Department of CTVS, SCB Medical College, Cuttack, Odisha, India
Satyajit Jena Assistant Professor, Department of Obstetrics and Gynaecology, SCB Medical College, Cuttack, Odisha, India,

DOI:

https://doi.org/10.51168/sjhrafrica.v4i12.915

Keywords:

Ketamine, Propofol, Ambulatory Analgesia

Abstract

Background:

Propofol alone produces effective anesthesia, but several respiratory and cardiovascular complications are observed with it. Propofol, along with ketamine, is known to reduce the side effects and produce a longer duration of anesthesia. This study aims to compare the efficiency of propofol alone and propofol and ketamine in combination for producing ambulatory anesthesia.

Method:

An observational comparative study was conducted prospectively. 100 patients participated in the study. They were divided into two groups. Group A was given propofol alone, and Group B was given propofol along with ketamine. The hemodynamic stability, duration of analgesia, and effectiveness of anesthesia were compared in both groups.

Results:

The average dose of induction for group A was 2 mg, and for group B was 1.6 mg. The average time for recovery from the induction dose for group A was 3 minutes, and for group B was 10 minutes. The average time of analgesia for group A was 9 minutes, and for group B, it was 49 minutes. Group B had improved hemodynamic stability and a longer duration of analgesia.

Conclusion:

From the findings of the study, it can be concluded that the propofol-ketamine combination for anesthetic gives improved hemodynamic stability, effective anesthesia, and a longer duration of analgesia compared to only propofol. The time of recovery from the induction dose was prolonged in the case of the combination compared to propofol alone.

Recommendation:

Propofol with a combination of ketamine produces effective anesthesia with a reduced adverse drug reaction, hence it should be preferred over propofol alone for ambulatory anesthesia.