A NARRATIVE REVIEW OF ADDRESSING FEMALE REPRODUCTIVE DISORDERS: THE POTENTIAL ROLE OF MELATONIN.

Abstract

Disorders pertaining to the female reproductive system, encompassing conditions related to hormone regulation, fertility, and fetal well-being, are of significant global apprehension. In recent times, the utilization of melatonin supplementation has emerged as a potential therapeutic modality within the field of gynecology. In various animal models as well as in female subjects, the administration of melatonin has demonstrated potential therapeutic and preventive effects. These effects are primarily attributed to the antioxidant properties of melatonin and its ability to modulate hormone activity. The primary objective of this comprehensive literature review is to delve deeper into the existing body of evidence pertaining to the impact of melatonin supplementation in both animal and human studies. The specific focus of this investigation is to explore the potential utility of melatonin supplementation in the field of gynecology. Melatonin-containing supplements are readily available for purchase through online and brick-and-mortar retailers. Although these supplements are generally considered safe for supplementation, there remains a lack of consensus regarding the optimal dosage and duration of supplementation. In the context of short-term supplementation investigations, typically spanning a duration of no more than six months, preliminary findings indicate that the administration of melatonin at a daily dosage ranging from 2 to 18 mg exhibits promising prospects in enhancing fertility rate, oocyte quality, maturation, and the quantity of embryos produced. The current body of evidence regarding the impact of melatonin supplementation on gestational age and gestational outcomes is notably limited. Further investigation is warranted to evaluate the potential clinical implications of melatonin supplementation within the realm of gynecology. This necessitates the implementation of clinical trials and extended supplementation studies to ascertain any discernible clinical outcomes.