A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER.

Prince  Kumar; Kumar  Prabhat

doi:10.51168/sjhrafrica.v4i12.824

Authors

Prince Kumar Senior Resident, Department of Radiation Oncology, IGIMS Patna, Bihar, India.
Kumar Prabhat Kumar Prabhat, Senior Resident, DMCH Darbhanga, Bihar, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v4i12.824

Keywords:

adaptive radiation therapy, small cell lung cancer, chemotherapy

Abstract

Background

Radiation therapy along with chemotherapy is proven to be effective in treating limited-stage small-cell lung cancer. However, the irradiation has deleterious effects on the other normal vital organs.

Aim

This study aimed to evaluate the efficacy and tolerability of adaptive radiation therapy in treating LS-SCLC.

Methodology

30 patients participated in this observational study. Radiation therapy was given in 30 fractions, each with 60 units. The first CT was used to determine the dose and the progress of the disease after which 15 sessions of radiation out of 30 were conducted. 20-25 days after the first CT and the 15 fractions, a mid-treatment CT was conducted to evaluate the dose of radiation received by the target organs and the other vital organs. A dosimetry evaluation was conducted, and statistical analysis was done.

Results

The decrease in the tumour volume was significant from 185 cubic centimeters it reduced to 53 cubic centimeters. The difference in the values from the first CT and the mid-treatment CT was found to be statistically significant. The effect on the vital organs was comparatively lesser than the conventional radiotherapy.

Conclusion

Adaptive radiation therapy is found to be effective in treating limited-stage small cell cancer as indicated by the tumor size volume in the initial and during the treatment CT scan

Recommendation

Dosimetry evaluation can serve as an effective tool in determining the effect of irradiation on the vital organs and developing a further treatment plan.