A CORRELATIONAL ANALYSIS OF CARDIAC AUTONOMIC NEUROPATHY, ARTERIAL STIFFNESS, AND LIPID PROFILE IN DIABETIC PATIENTS
DOI:
https://doi.org/10.51168/sjhrafrica.v4i9.666Keywords:
Type 2 diabetes mellitus, Arterial stiffness, Cardiac autonomic neuropathy (CAN), Heart rate variability, Lipid profileAbstract
Objective:
It is necessary to comprehend the mechanistic connections between cardiovascular risk factors. This is the foundation for the present investigation.
Materials and Methods:
In the cross-sectional and observational research, patients with T2DM aged 53 to 62 years and age- and gender-matched healthy control subjects were recruited (n = 30 each, eight women). After obtaining the participants' consent, anthropometric measurements, physiological parameters including resting heart rate, peripheral blood pressure (PBP), central blood pressure (CBP), augmentation index% (AIx%), brachial-ankle pulse wave velocity, and lead II ECG for analysis of heart rate variability parameters were obtained. In addition, the lipid profile and fasting blood glucose were evaluated.
Results:
In T2DM patients, peripheral systolic blood pressure was significantly higher (P = 0.05). Patients with T2DM demonstrated dyslipidemia. In T2DM patients, the atherogenic index of plasma (AIP) was also significantly higher. The AIP index was discovered to have a negative association with HF. Multiple regression analysis identifies serum TG, high-density lipoprotein cholesterol (HDL-C), and AIP index as independent predictors of T2DM vasculopathy.
Conclusion:
Atherogenic dyslipidaemia was observed in T2DM patients in conjunction with elevated serum levels of TG, VLDL-C, and decreased serum levels of HDL-C in the present study. In addition, the AIP index, a predictor of cardiovascular risk, was significantly greater in T2DM patients. In these patients, dyslipidaemia was discovered to be associated with dysregulation of the autonomic nervous system.
Recommendation:
Recommendations for the treatment of CAN include early optimization of blood glucose regulation to avoid or delay the development of CAN in people with T1DM.
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Copyright (c) 2023 Santosh Kumar, Neera Kumari
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