A CORRELATIONAL ANALYSIS OF CARDIAC AUTONOMIC NEUROPATHY, ARTERIAL STIFFNESS, AND LIPID PROFILE IN DIABETIC PATIENTS
Keywords:Type 2 diabetes mellitus, Arterial stiffness, Cardiac autonomic neuropathy (CAN), Heart rate variability, Lipid profile
It is necessary to comprehend the mechanistic connections between cardiovascular risk factors. This is the foundation for the present investigation.
Materials and Methods:
In the cross-sectional and observational research, patients with T2DM aged 53 to 62 years and age- and gender-matched healthy control subjects were recruited (n = 30 each, eight women). After obtaining the participants' consent, anthropometric measurements, physiological parameters including resting heart rate, peripheral blood pressure (PBP), central blood pressure (CBP), augmentation index% (AIx%), brachial-ankle pulse wave velocity, and lead II ECG for analysis of heart rate variability parameters were obtained. In addition, the lipid profile and fasting blood glucose were evaluated.
In T2DM patients, peripheral systolic blood pressure was significantly higher (P = 0.05). Patients with T2DM demonstrated dyslipidemia. In T2DM patients, the atherogenic index of plasma (AIP) was also significantly higher. The AIP index was discovered to have a negative association with HF. Multiple regression analysis identifies serum TG, high-density lipoprotein cholesterol (HDL-C), and AIP index as independent predictors of T2DM vasculopathy.
Atherogenic dyslipidaemia was observed in T2DM patients in conjunction with elevated serum levels of TG, VLDL-C, and decreased serum levels of HDL-C in the present study. In addition, the AIP index, a predictor of cardiovascular risk, was significantly greater in T2DM patients. In these patients, dyslipidaemia was discovered to be associated with dysregulation of the autonomic nervous system.
Recommendations for the treatment of CAN include early optimization of blood glucose regulation to avoid or delay the development of CAN in people with T1DM.
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Copyright (c) 2023 Santosh Kumar, Neera Kumari
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