“EFFECT OF SILDENAFIL ON ENDOMETRIAL THICKNESS AND UTERINE ARTERY BLOOD FLOW IN INFERTILE WOMEN

Chandani  Singh; Pragya  Khugsal; Vandana  Rajput; Shubha  Pandey

Authors

Chandani Singh Consultant gynecologist Vardan hospital, motihari , Bihar, India
Pragya Khugsal Assistant Professor, Department of obstetrics and gynaecology, Himalayan Institute of Medical Sciences, Dehradun
Vandana Rajput Consultant, Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Sciences, Dehradun
Shubha Pandey HOD, Department of obstetrics and gynecology, Kamla Nehru Memorial Hospital, Prayagraj, U.P. India

Keywords:

endometrial, thickness, sildenafil, citrate, estradiol, valerate

Abstract

Background: The increasing infertility in women, the present study was undertaken to evaluate and compare the effect of sildenafil citrate and Estradiol valerate on the endometrial thickness, endometrial pattern, and uterine blood flow of infertile women undergoing ovulation induction by Clomiphene citrate.

Methods: This was a 1-year prospective study on infertile females attending OPD at KNMH, Prayagraj.Study who were screened on the basis of inclusion and exclusion criteria

Results:

In the sildenafil group, there was a significant(p<0.05) improvement in endometrial thickness, uterine artery blood flow(Pulsatility Index of uterine artery), and endometrial

pattern and pregnancy rates as compared to the only estradiol valerate group.

Conclusion: There was a significant statistical difference between the two groups in terms of endometrial thickness, uterine artery blood flow(Pulsatility Index of uterine artery), and endometrial pattern before and after sildenafil citrate administration. Though both estradiol valerate and sildenafil citrate are effective in improving endometrial thickness, uterine artery blood flow, and endometrial pattern, sildenafil citrate is superior to estradiol valerate.

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