Association of sun exposure, hormonal factors, and cosmetic use with melasma: An observational study in urban Indian women.

Authors

  • Dr. R. Meenakshi Assistant Professor, Department of Dermatology, Venereology and Leprosy, Government Medical College and General Hospital, Nalgonda, Telangana, India.
  • Dr. S. Vasantha Kumari Associate Professor, Department of Dermatology, Venereology and Leprosy, Government Medical College and General Hospital, Narsampet, Warangal District, Telangana, India.
  • Dr. Prashanthi Mogili Assistant Professor, Department of Dermatology, Venereology and Leprosy, Government Medical College and General Hospital, Janagaon, Telangana, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v6i12.2183

Keywords:

Melasma, Sun exposure, Hormonal factors, Oral contraceptives, Cosmetic use, Urban Indian women, Photoprotection, mMASI score

Abstract

Background:
Melasma is a common acquired hypermelanosis characterized by irregular brown macules, predominantly affecting women with darker skin types.

Objectives:

To evaluate the association of sun exposure, hormonal factors, and cosmetic use with the clinical patterns and severity of melasma among urban Indian women.

Methods:

A cross-sectional observational study was conducted among 100 women clinically diagnosed with melasma attending a tertiary dermatology outpatient clinic in urban India. Data on demographic profile, duration of sun exposure, hormonal history (pregnancy, oral contraceptive use), and cosmetic usage were collected using a structured questionnaire. Clinical evaluation included pattern classification and severity assessment using the Modified Melasma Area and Severity Index (mMASI). Statistical significance of associations was analyzed using the chi-square test, with p < 0.05 considered significant.

Results:

The mean age of participants was 34.8 ± 6.7 years, with the majority in the 30–40-year group (58%). The malar pattern (52%) was most frequent, followed by centrofacial (38%) and mandibular (10%) types. Moderate-to-severe melasma was noted in 54% of women. Significant associations were found with sun exposure >2 hours/day (p < 0.01), hormonal influences including pregnancy and OCP use (p = 0.02), and regular cosmetic use (p = 0.03). Family history of melasma was observed in 34% of participants, predominantly among those with Fitzpatrick skin type IV.

Conclusion:

Melasma among Indian women shows a clear association with prolonged sun exposure, hormonal influences, and regular cosmetic use. The predominance of malar and centrofacial patterns, particularly in women with Fitzpatrick skin type IV, highlights the combined impact of environmental triggers and genetic predisposition.

Recommendations:

Dermatologists should incorporate counseling on UV protection, screening for hormonal triggers, and guidance on safe cosmetic practices into routine management protocols for melasma. Longitudinal studies are recommended to assess the long-term impact of behavioral modification and hormonal regulation on melasma recurrence.

 

References

Ali L, Al Niaimi F. Pathogenesis of Melasma Explained. Int J Dermatol. 2025 Jul;64(7):1201-1212. doi: 10.1111/ijd.17718. Epub 2025 Feb 28. PMID: 40022484; PMCID: PMC12207721.

Liu W, Chen Q, Xia Y. New Mechanistic Insights of Melasma. Clin Cosmet Investig Dermatol. 2023 Feb 13;16:429-442. doi: 10.2147/CCID.S396272. PMID: 36817641; PMCID: PMC9936885.

Platsidaki E, Markantoni V, Nicolaidou E, Katoulis A, Rigopoulos D, Stratigos AJ, et al. Melasma: A Clinical and Epidemiological Single-Group Observational Study in the Greek Population. Dermatol Ther (Heidelb). 2024 Nov;14(11):3183-3192. doi: 10.1007/s13555-024-01297-8. Epub 2024 Nov 1. PMID: 39485595; PMCID: PMC11557805.

Cheng D, Gaurav A, Xiang D, Ji H, Hirsh DA, Chen ST, et al. Hormonal Intrauterine Devices Are Associated With Lower Long-Term Melasma Risk Compared With Combined and Progestin-Only Oral Contraceptives: A Population-Based Cohort Study. J Am Acad Dermatol. 2025 Aug;93(2):473-475. doi: 10.1016/j.jaad.2025.04.040. Epub 2025 Apr 24. PMID: 40286818.

Qu Y, Wang S, Xie H, Meng X, Cui B, Xiao Z. Melasma secondary to drugs: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS). BMC Pharmacol Toxicol. 2025 Mar 31;26(1):73. doi: 10.1186/s40360-025-00912-4. PMID: 40165336; PMCID: PMC11956175.

Alshammari F, Alheibshy F, Alobaida A, Alhamad MQ, Alrashidi OA, Alharbi OR, et al. Hydroquinone Levels in Unregulated Skin-Lightening Creams and Women's Knowledge, Attitudes, and Practices Toward Skin-Lightening Products in Hail, Saudi Arabia. Patient Prefer Adherence. 2025 Aug 5;19:2309-2318. doi: 10.2147/PPA.S514993. PMID: 40785839; PMCID: PMC12335261.

Grimes PE, Paturi J, Chen Y, Wangari-Olivero J, Dumbuya H, Yan X, et al. Photoprotection Efficacy of Sun Protection Factor and Iron Oxide Formulations in Diverse Skin With Melasma and Photodamage. J Drugs Dermatol. 2025 Jul 1;24(7):662-667. doi: 10.36849/JDD.9240. PMID: 40627587.

Polena H, Queille-Roussel C, Graizeau C, Duteil L, Sayag M, Passeron T. Comparison of Visible Light-Protective Tinted Sunscreen to Untinted Sunscreen to Protect Melasma Patients During Summer: A Prospective Randomized Investigator-Blinded Study. J Cosmet Dermatol. 2025 Oct;24(10):e70450. doi: 10.1111/jocd.70450. PMID: 41014037; PMCID: PMC12475913.

Abou-Taleb DA, Ibrahim AK, Youssef EM, Moubasher AE. Reliability, Validity, and Sensitivity to Change Overtime of the Modified Melasma Area and Severity Index Score. Dermatol Surg. 2017 Feb;43(2):210-217. doi: 10.1097/DSS.0000000000000974. PMID: 27930379.

Pandya AG, Hynan LS, Bhore R, Riley FC, Guevara IL, Grimes P, et al. Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method. J Am Acad Dermatol. 2011 Jan;64(1):78-83, 83.e1-2. doi: 10.1016/j.jaad.2009.10.051. Epub 2010 Apr 15. PMID: 20398960.

Philipp-Dormston WG. Melasma: A Step-by-Step Approach Towards a Multimodal Combination Therapy. Clin Cosmet Investig Dermatol. 2024 May 22;17:1203-1216. doi: 10.2147/CCID.S372456. PMID: 38800358; PMCID: PMC11128260.

Shakya S, Pathak BD, Lamichhane R, Ghimire B, Devkota S, Ghimire S, et al. Risk factors and severity of melasma in patients attending dermatology outpatient department of a tertiary care hospital: A cross-sectional study. Medicine (Baltimore). 2024 Sep 13;103(37):e39674. doi: 10.1097/MD.0000000000039674. PMID: 39287320; PMCID: PMC11404921.

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Published

2025-09-30

How to Cite

Dr. R. Meenakshi, Kumari, V. ., & Mogili, P. . (2025). Association of sun exposure, hormonal factors, and cosmetic use with melasma: An observational study in urban Indian women. Student’s Journal of Health Research Africa, 6(9), 8. https://doi.org/10.51168/sjhrafrica.v6i12.2183

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Section

Section of Dermatology and Venereology Research