A comparative study of spinal bupivacaine with fentanyl versus ultrasound-guided combined lumbar plexus and sciatic nerve block in lower limb orthopedic procedures: A prospective randomized controlled trial.

Authors

  • Lathika G Assistant Professor, Department of Anaesthesiology, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India, under The Tamil Nadu Dr. M.G.R. Medical University, Chennai.
  • Dr. Rajaram M Senior Resident, Department of Anaesthesiology, Government Hospital, Ulundurpet, Kallakurichi, Tamil Nadu, India, under The Tamil Nadu Dr. M.G.R. Medical University, Chennai.
  • Dr. Elakkiya.G Assistant Surgeon, Department of Anaesthesiology, Government Hospital, Kattumannarkoil, Tamil Nadu, India, under The Tamil Nadu Dr. M.G.R. Medical University, Chennai.
  • Dr.Panneerselvam Periasamy Assistant Professor, Department of Physiology, Government Erode Medical College, Perundurai, Tamil Nadu, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v6i6.1974

Keywords:

Spinal anesthesia, bupivacaine, fentanyl, lumbar plexus block, sciatic nerve block, regional anesthesia, orthopedic surgery

Abstract

Background
Spinal anesthesia with bupivacaine and fentanyl is widely used for its rapid onset, while ultrasound-guided lumbar plexus and sciatic nerve blocks are gaining popularity for prolonged postoperative analgesia with fewer systemic side effects. Aim: To compare the efficacy of spinal bupivacaine with fentanyl versus ultrasound-guided combined lumbar plexus and sciatic nerve blocks in lower limb orthopedic procedures.

Methods

This prospective randomized controlled trial was conducted on 50 patients aged 18–65 years undergoing elective lower limb orthopedic surgeries. Patients were randomized into two groups: Group A received spinal bupivacaine (12.5 mg) + fentanyl (25 mcg); Group B received ultrasound-guided lumbar plexus block with 30 ml of 0.25% bupivacaine and sciatic nerve block with 25 ml of 0.25% bupivacaine. Primary outcomes included onset and duration of sensory and motor blocks, and duration of analgesia. Secondary outcomes included hemodynamic changes and complications.

Results

Both groups were comparable in baseline demographics, with a mean age of 49 years and a similar distribution of sex and ASA physical status. The onset of sensory and motor block was significantly faster in Group A (5–8 min and 6–10 min) compared to Group B (10–20 min and 12–20 min; p<0.001). However, Group B had a significantly longer duration of sensory block (6–8 hrs), motor block (3–4 hrs), and analgesia (8–12 hrs) (p<0.001). Hypotension was more common in Group A (48%) than in Group B (32%). Two patients in Group B required conversion to general anesthesia due to technical difficulties.

Conclusion

Ultrasound-guided lumbar plexus and sciatic nerve blocks provide longer postoperative analgesia with fewer hemodynamic changes, making them preferable in high-risk or prolonged orthopedic surgeries.

Recommendations

For lower limb orthopedic surgeries, ultrasound-guided lumbar plexus and sciatic nerve blocks are recommended, particularly in patients at risk of hemodynamic instability or requiring prolonged analgesia.

 

References

Bansal L, Attri JP, Verma P. Lower limb surgeries under combined femoral and sciatic nerve block. Anesth Essays Res. 2016 Sep-Dec;10(3):432-436. doi: 10.4103/0259-1162.177186. PMID: 27746528; PMCID: PMC5062190.

Tharwat AI. Combined posterior lumbar plexus-sciatic nerve block versus combined femoral-obturator-sciatic nerve block for ACL reconstruction. Local Reg Anesth. 2011;4:1-6. doi: 10.2147/LRA.S15635. Epub 2011 Feb 9. PMID: 22915884; PMCID: PMC3417964.

Aksoy M, Dostbil A, Ince I, Ahiskalioglu A, Alici HA, Aydin A, Kilinc OO. Continuous spinal anaesthesia versus ultrasound-guided combined psoas compartment-sciatic nerve block for hip replacement surgery in elderly high-risk patients: a prospective randomised study. BMC Anesthesiol. 2014 Nov 5;14:99. doi: 10.1186/1471-2253-14-99. PMID: 25414593; PMCID: PMC4237736.

Amiri HR, Safari S, Makarem J, Rahimi M, Jahanshahi B. Comparison of combined femoral nerve block and spinal anesthesia with lumbar plexus block for postoperative analgesia in intertrochanteric fracture surgery. Anesth Pain Med. 2012 Summer;2(1):32-5. doi: 10.5812/aapm.4526. Epub 2012 Jul 10. PMID: 24223331; PMCID: PMC3821105.

Kendall MC, Alves LJC, Suh EI, McCormick ZL, De Oliveira GS. Regional anesthesia to ameliorate postoperative analgesia outcomes in pediatric surgical patients: an updated systematic review of randomized controlled trials. Local Reg Anesth. 2018 Nov 15;11:91-109. doi: 10.2147/LRA.S185554. PMID: 30532585; PMCID: PMC6244583.

Bajwa SJ, Kaur J. Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9. doi: 10.4103/0970-9185.119172. PMID: 24249993; PMCID: PMC3819850.

Kamel I, Ahmed MF, Sethi A. Regional anesthesia for orthopedic procedures: What orthopedic surgeons need to know. World J Orthop. 2022 Jan 18;13(1):11-35. doi: 10.5312/wjo.v13.i1.11. PMID: 35096534; PMCID: PMC8771411.

Vanterpool S, Steele SM, Nielsen KC, Tucker M, Klein SM. Combined lumbar-plexus and sciatic-nerve blocks: an analysis of plasma ropivacaine concentrations. Reg Anesth Pain Med. 2006 Sep-Oct;31(5):417-21. doi: 10.1016/j.rapm.2006.06.007. PMID: 16952812.

Abrahams MS, Horn JL, Noles LM, Aziz MF. Evidence-based medicine: ultrasound guidance for truncal blocks. Reg Anesth Pain Med. 2010 Mar-Apr;35(2 Suppl):S36-42. doi: 10.1097/AAP.0b013e3181d32841. PMID: 20216023.

Iwata T, Lakshman S, Singh A, Yufa M, Claudio R, Hadzić A. Peripheral nerve blocks for perioperative management of patients having orthopedic surgery or trauma of the lower extremity. Bosn J Basic Med Sci. 2005 May;5(2):5-19. doi: 10.17305/bjbms.2005.3278. PMID: 16053449; PMCID: PMC7214073.

Tetzlaff JE. Cousins and Bridenbaugh's Neural Blockade in Clinical Anesthesia and Pain Medicine. Mayo Clin Proc. 2010 Jul;85(7):e51. doi: 10.4065/mcp.2010.0230. PMCID: PMC2894732.

Downloads

Published

2025-06-30

How to Cite

Lathika G, Dr. Rajaram M, Elakkiya.G, & Periasamy, P. . (2025). A comparative study of spinal bupivacaine with fentanyl versus ultrasound-guided combined lumbar plexus and sciatic nerve block in lower limb orthopedic procedures: A prospective randomized controlled trial. Student’s Journal of Health Research Africa, 6(6), 9. https://doi.org/10.51168/sjhrafrica.v6i6.1974

Issue

Section

Section of Anesthesia and Surgery Research