A Study of Liver Function Tests Derrangements in Leptospirosis

Bikash Chandra  Nanda; Manoranjan  Naik; Balaram  Khamari

Authors

Bikash Chandra Nanda Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India
Manoranjan Naik Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India
Balaram Khamari Senior Resident, Department of General Medicine, VIMSAR, Burla, Odisha, India

Keywords:

LFT, SGOT Level, SGPT Level, Leptospirosis, Duration of Hospital Stay

Abstract

Background- A zoonotic illness that is found all throughout the world is leptospirosis. For growth, leptospires need specific media and circumstances. Positive cultural shifts might occur over the course of weeks or months. Clinical, diagnostic, and epidemiologic objectives are best served by classifications based on serologic distinctions.

Objectives- Based on indications and symptoms, the study aims to determine the distribution of leptospirosis patients. Identifying the correlation between clinical factors at admission and six weeks later in leptospirosis patients is another goal.

Materials and Methods- The study was observational and prospective. The study was conducted in Burla, Sambalpur, Odisha, India, at the Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR). The research was conducted between February 2024 and January 2025. One hundred patients in all were enrolled in the trial.

Results- Signs and symptoms included tachycardia, icterus, conjunctival congestion, oliguria, hypotension, hepatomegaly, subconjunctival hemorrhage, fever, myalgia, headache, vomiting, abdominal pain, rashes, and arthralgia. All the 100 (100%) patients had fever along with myalgia. All the parameters including AST, ALT, total bilirubin, direct bilirubin, ALP, total protein, and albumin were found to be statistically significant at baseline and after 6 weeks.

Conclusion- The study came to the conclusion that elevated levels of bilirubin and transaminases were the primary way that the liver was involved in leptospirosis. Patients' bilirubin, AST, and ALT levels were much lower at 6 weeks than they were at admission.

Author Biographies

Bikash Chandra Nanda, Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India

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Manoranjan Naik, Assistant Professor, Department of General Medicine, VIMSAR, Burla, Odisha, India

, (

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