A RETROSPECTIVE COHORT STUDY EXAMINING THE RELATIONSHIP BETWEEN 30-DAY MORTALITY AND HIGH-SENSITIVITY TROPONIN T LEVELS BEFORE AND AFTER CARDIAC SURGERY.

Tushar  Kumar; Aandrei J  Jha; Madhav  Kumar

doi:10.51168/sjhrafrica.v6i3.1613

Authors

Tushar Kumar Associate Professor, CTVS Department, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
Aandrei J Jha Associate Professor, CTVS Department, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
Madhav Kumar Associate Professor, CTVS Department, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India

DOI:

https://doi.org/10.51168/sjhrafrica.v6i3.1613

Keywords:

High-Sensitivity Troponin T, Cardiac Surgery, Postoperative Outcomes, 30-Day Mortality

Abstract

Background:

Elevated troponin levels have been linked to adverse outcomes in cardiac surgery patients, but the specific impact of high-sensitivity troponin T (hs-TnT) measured before and after surgery on short-term mortality remains unclear. This study analyses a retrospective cohort to determine the reliability of hs-TnT readings as early mortality prognostic markers and their potential to improve perioperative treatment.

Methods:

In this retrospective cohort analysis, we examined 200 heart surgery patients at the Indira Gandhi Institute of Medical Sciences, Patna, over 24 months (January 2023 – January 2025). After controlling for age, gender, operation type, and comorbidities, we investigated preoperative and postoperative hs-TnT levels and 30-day mortality.

Results:

This retrospective study of 200 cardiac surgery patients (mean age 63 years) demonstrated that elevated postoperative hs-TnT levels above 150 ng/L were associated with a significantly higher risk of 30-day mortality, with an odds ratio of 4.5 (p < 0.001). Preoperative hs-TnT levels did not show a significant correlation with mortality. When adjusted for confounding factors, the highest quartile of postoperative hs-TnT levels was linked to a 4-fold increased mortality risk (adjusted OR = 4.0, p = 0.003). These findings suggest that monitoring hs-TnT levels post-surgery could be critical for predicting early mortality in cardiac surgery patients.

Conclusion:

Elevated postoperative hs-TnT levels are a strong predictor of 30-day mortality in cardiac surgery patients. Monitoring hs-TnT levels could be essential for identifying at-risk patients and enhancing postoperative care.

Recommendation:

Postoperative hs-TnT levels should be routinely monitored to predict 30-day mortality risk in cardiac surgery patients.

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