Adherence to IPT among HIV adolescents aged 11 to 19 years at Kisenyi health center IV, Kampala district. A cross-sectional study.
DOI:
https://doi.org/10.51168/sjhrafrica.v6i9.1546Keywords:
Adherence, IPT, Adolescents, Kisenyi Health Centre IVAbstract
Background
Adherence to Isoniazid Preventive Therapy (IPT) is crucial for HIV-positive adolescents to prevent tuberculosis (TB). When forfeited, it poses severe health risks. This study thus aimed at exploring the factors influencing adherence to IPT among HIV-positive adolescents aged 11 to 19 years, focusing on socioeconomic, individual, and health facility-related factors.
Methodology
A descriptive cross-sectional study design was employed, involving 30 HIV-positive adolescents selected through simple random sampling. Data was collected using structured questionnaires translated into the local language for better comprehension. The collected data were analyzed using Microsoft Excel, and the results were presented in tables and figures.
Results
The study involved more females (20, 67%) than males (10, 33%), with the majority (70%) aged between 17 and 19 years and not living with their parents or guardians (21, 70%). Findings revealed significant socioeconomic challenges, with 56% of respondents reporting struggles to afford basic needs, which influenced adherence to IPT. Most participants (60%) found it difficult to access the health center for appointments. On individual factors, 70% of adolescents had a limited understanding of IPT benefits, while 80% expressed concern about potential side effects, negatively influencing adherence. Additionally, 70% had stigma associated with taking IPT, leading to treatment avoidance. Positively, 60% of respondents had stable housing, and 80% felt confident in managing IPT as part of their lives. Regarding health facility factors, 70% reported long wait time, while 80% noted consistent availability of IPT medication, which supported adherence.
Conclusion
Adherence to IPT among HIV-positive adolescents at Kisenyi Health Center IV is influenced by various factors such as low socio-economic status and long wait hours, which impede access to health care.
Recommendation
Implementation of targeted educational programs, enhancing access to healthcare services, training staff for supportive interactions, and developing reminder systems to help adolescents manage their medication routines.
References
Amuge, P. M., Ndekezi, D., Mugerwa, M., Bbuye, D., Rutebarika, D. A., Kizza, L., Namugwanya, C., Baita, A., Elyanu, P. J., Ntege, P. N., Kiragga, D., Birungi, C., Kekitiinwa, A. R., Kiragga, A., Sekadde, M. P., Salazar-Austin, N., Mandalakas, A. M., & Musoke, P. (2024). Correction: Facilitators and barriers to initiating and completing tuberculosis preventive treatment among children and adolescents living with HIV in Uganda: a qualitative study of adolescents, caretakers and health workers. AIDS Research and Therapy, 21(1), 61. https://doi.org/10.1186/s12981-024-00651-2
Gupta, A. J., Turimumahoro, P., Ochom, E., Ggita, J. M., Babirye, D., Ayakaka, I., Mark, D., Okello, D. A., Cattamanchi, A., Dowdy, D. W., Haberer, J. E., Armstrong-Hough, M., Katamba, A., & Davis, J. L. (2023). mHealth to improve implementation of TB contact investigation: A case study from Uganda. Implementation Science Communications, 4(1), 71. https://doi.org/10.1186/s43058-023-00448-w
Harries, A. D., Kumar, A. M. V., Satyanarayana, S., Thekkur, P., Lin, Y., Dlodlo, R. A., Khogali, M., & Zachariah, R. (2020). The Growing Importance of Tuberculosis Preventive Therapy and How Research and Innovation Can Enhance Its Implementation on the Ground. Tropical Medicine and Infectious Disease, 5(2), 61. https://doi.org/10.3390/tropicalmed5020061
Hlophe, L. D., Tamuzi, J. L., Shumba, C. S., & Nyasulu, P. S. (2023). Barriers and facilitators to anti-retroviral therapy adherence among adolescents aged 10 to 19 years living with HIV in sub-Saharan Africa: A mixed-methods systematic review and meta-analysis. PLOS ONE, 18(5), e0276411. https://doi.org/10.1371/journal.pone.0276411
Kay, A. W., González Fernández, L., Takwoingi, Y., Eisenhut, M., Detjen, A. K., Steingart, K. R., & Mandalakas, A. M. (2020). Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD013359.pub2
Mandalakas, A. M., Hesseling, A. C., Kay, A., Du Preez, K., Martinez, L., Ronge, L., DiNardo, A., Lange, C., & Kirchner, H. L. (2021). Tuberculosis prevention in children: A prospective community-based study in South Africa. European Respiratory Journal, 57(4), 2003028. https://doi.org/10.1183/13993003.03028-2020
Mandalakas, A. M., Kay, A. W., Bacha, J. M., Devezin, T., Golin, R., Simon, K. R., Dhillon, D., Dlamini, S., DiNardo, A., Matshaba, M., Sanders, J., Thahane, L., Amuge, P. M., Ahmed, S., Sekadde, M. P., Fida, N. G., Lukhele, B., Chidah, N., Damba, D., … Schutze, G. E. (2020). Tuberculosis among Children and Adolescents at HIV Treatment Centers in Sub-Saharan Africa. Emerging Infectious Diseases, 26(12). https://doi.org/10.3201/eid2612.202245
Mwangi, P., Wamalwa, D., Marangu, D., Obimbo, E., & Ng’ang’a, M. (2019). Implementation of Isoniazid Preventive Therapy Among HIV-Infected Children at Health Facilities in Nairobi County, Kenya: A Cross-Sectional Study. East African Health Research Journal, Vol 3(No 2), 141–150. https://doi.org/10.24248/eahrj.v3i2.611
Müller, P., & Velez Lapão, L. (2022). Mixed methods systematic review and metasummary
a. about barriers and facilitators for the implementation of cotrimoxazole and isoniazid—Preventive therapies for people living with HIV. PLoS One, 17(3), e0251612.
Ngugi, S. K., Muiruri, P., Odero, T., & Gachuno, O. (2020). Factors affecting uptake and completion of isoniazid preventive therapy among HIV-infected children at a national referral hospital, Kenya: A mixed quantitative and qualitative study. BMC Infectious Diseases, 20(1), 294. https://doi.org/10.1186/s12879-020-05011-9
Selehelo, K. (n.d.). Experiences of people living with HIV with respect to Isoniazid Preventive Therapy provision in Mafikeng PHC facilities.
Sm, A. (2019). Initiation appropriateness, adverse drug reaction and adherence of isoniazid prophylaxis therapy among people living with human immune virus in Eastern Ethiopia: A cross-sectional study. 2(1).
Ssendikwanawa, E., Juniour Nsubuga, E., Lee, S., Frances Zalwango, J., Joan Bayowa, R., Judith Ssemasaazi, A., Ronald Muganga, K., Adolphus, C., Akunzirwe, R., Nante Wangi, R., Ronald Kasoma, M., Kalyango, J. N., Karamagi, C., & Sekaggya-Wiltshire, C. (2023). Factors associated with isoniazid preventive treatment interruption and completion among PLHIV in Gombe Hospital, Uganda, 2017–2019. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 31, 100349. https://doi.org/10.1016/j.jctube.2023.100349
Villiera, J. B., Katsabola, H., Bvumbwe, M., Mhango, J., Khosa, J., Silverstein, A., & Nyondo-Mipando, A. L. (2022). Factors associated with antiretroviral therapy adherence among adolescents living with HIV in the era of isoniazid preventive therapy as part of HIV care. PLOS Global Public Health, 2(6), e0000418. https://doi.org/10.1371/journal.pgph.0000418
Wambiya, E. O. A., Atela, M., Eboreime, E., & Ibisomi, L. (2018). Factors affecting the acceptability of isoniazid preventive therapy among healthcare providers in selected HIV clinics in Nairobi County, Kenya: A qualitative study. BMJ Open, 8(12), e024286. https://doi.org/10.1136/bmjopen-2018-024286
Wong, J.S. and Burton, T.A. (1965) Some Properties of Solution of . Monatshefte für Mathematik, 69, 364-674.
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