ASSESSMENT OF THE RELATIONSHIP BETWEEN SERUM ALBUMIN AND GLUCOSE LEVELS IN HEALTHY, PRE-DIABETIC, AND DIABETIC INDIVIDUALS’ CASE-CONTROL OBSERVATIONAL STUDY

Kanchan  Kumari; Swati  sinha; Ajay kumar  singh; Vaidehi; Yogesh Krishna  Sahay

doi:10.51168/sjhrafrica.v5i12.1439

Authors

Kanchan Kumari Associate Professor ,Dept. of Biochemistry, Bhagwan Mahavir Institute of Medical Sciences, Pawapuri,Nalanda,Bihar,India
Swati sinha Associate Professor ,Department of Physiology , Bhagwan Mahavir Institute of Medical Sciences, Pawapuri,Nalanda,Bihar,India
Ajay kumar singh Tutor, Department of Physiology , Bhagwan Mahavir Institute of Medical Sciences, Pawapuri,Nalanda,Bihar,India
Vaidehi Tutor, Department of Biochemistry , Bhagwan Mahavir Institute of Medical Sciences,Pawapuri,Nalanda,Bihar,India
Yogesh Krishna Sahay professor &HOD, Department of Biochemistry, Bhagwan Mahavir Institute of Medical Sciences, Pawapuri,Nalanda,Bihar,India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i12.1439

Keywords:

Pre-diabetic, Diabetic, Serum Albumin, FBG, PPBG

Abstract

Introduction

Diabetes mellitus is a metabolic disorder characterized by chronic persistent hyperglycemia. If it persists for a prolonged period, it may lead to microvascular and macrovascular complications. Several studies were done to estimate serum albumin in diabetes mellitus, and there is uncertainty about the relationship between serum albumin and diabetes.

Aim and objectives

The aim of this study is to compare serum albumin in normal, pre-diabetic, and diabetic individuals.

Materials and methods

Glucose estimation was done using the Glucose oxidase Peroxidase method, and Albumin estimation was done using the Bromocresol Green method in Pawapuri, Nalanda.

Results

A total of 160 cases of age between 30-80 years were selected out of which 40 each were healthy, pre-diabetic, diabetic with Glucose levels less than 300mg/dl and above 300mg/dl. The mean Serum albumin level with standard deviation in normal individuals was 4.63± 30, in pre-diabetic individuals was 4.38 ± 0.24, in diabetic individuals were 4.23 ± 0.41, in uncontrolled diabetic individuals were3.98± 0.35. There was a significant decrease in serum albumin in pre-diabetic, diabetic, and uncontrolled diabetic individuals from normal individuals.

Conclusion

There was an inverse relationship between serum Albumin and Glucose in diabetic individuals. By regular estimation of serum albumin in diabetic individuals, the development of complications in diabetic individuals can be delayed.

Recommendation

Regular estimation of serum albumin levels in diabetes and keeping serum albumin levels within normal limits is required to delay diabetic complication development.

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