Comparing Serum Cystatin C and Serum Creatinine as Early Markers for Acute Renal Dysfunction in Intensive Care Patients: A Cross-Sectional Analysis.

Authors

  • Roli Bharti Assistant Professor, Department of Obstetrics & Gynaecology, Jawahar Lal Nehru Medical College & Hospital, Bhagalpur, Bihar, India.
  • Anand Sinha Assistant Professor, Department of Medicine, Jawahar Lal Nehru Medical College & Hospital, Bhagalpur, Bihar, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v5i6.1274

Keywords:

Acute renal dysfunction, biomarkers, cystatin C, serum creatinine

Abstract

Background: Acute renal dysfunction is a critical concern in intensive care units (ICUs), associated with increased morbidity and mortality. Early detection is essential, and serum biomarkers like cystatin C and serum creatinine have shown promise. This study aimed to assess their utility in identifying acute renal dysfunction.

Methods: A cross-sectional case-control study involving 960 ICU patients was conducted. Age and gender matching were ensured between control and case groups. Serum cystatin C and serum creatinine were evaluated and analyzed. Comparative and ROC curve analysis was performed to evaluate the biomarkers' relevance.

Results: The study found age and gender matching, validating the control-case group comparisons. Serum cystatin C consistently distinguished between groups, demonstrating its potential as an early marker. Comparative analysis and ROC curve analysis supported the relevance of these biomarkers. Cystatin C exhibited superior sensitivity and specificity.

Conclusion: Serum cystatin C and serum creatinine are valuable biomarkers for early detection of acute renal dysfunction in ICUs. Their consistent differentiation between control and case groups highlights their significance in critical care settings.

Recommendations: These biomarkers should be routinely considered for early assessment of acute renal dysfunction in ICUs. Further research is warranted to refine their clinical utility.

Published

2024-06-30

How to Cite

Bharti, R. ., & Anand Sinha. (2024). Comparing Serum Cystatin C and Serum Creatinine as Early Markers for Acute Renal Dysfunction in Intensive Care Patients: A Cross-Sectional Analysis. Student’s Journal of Health Research Africa, 5(6). https://doi.org/10.51168/sjhrafrica.v5i6.1274

Issue

Section

Section of Obstetrics and Gynecology Research