Incidence of Prediabetes and Diabetes in Women with Previous Gestational Diabetes and Non-Alcoholic Fatty Liver Disease: A Prospective Study


  • Rajesh Ranjan Behera Consultant, Department of General Medicine, Kalinga institute of medical sciences (KIIMS), India
  • Manisha Kumari Senior Resident, Department of Obstetrics & Gynaecology, IMS & SUM Hospital, India



Non-Alcoholic Fatty Liver Disease, Gestational Diabetes Mellitus, Prediabetes, Type 2 Diabetes Mellitus, Glycaemic Progression


Background: Non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM) are two common metabolic disorders that have similar pathophysiological mechanisms, including chronic inflammation and resistance to insulin. The objective of this research was to examine the prevalence of prediabetes and diabetes in females who had previously experienced GDM and NAFLD, and to determine the variables linked to the advancement of glycaemic categories within this cohort.

Methods: The study included 230 women who were evaluated for NAFLD at a baseline postpartum visit. The participants were categorized based on their GDM status during pregnancy and NAFLD presence. Incidence rates of prediabetes and diabetes were calculated, and significant predictors of glycaemic progression were identified. Data collection included medical history, anthropometric measurements, and biochemical parameters. Statistical analyses were performed using Stata 15.0.

Results: In 98 (42.6%) of the women, prediabetes or diabetes developed over a median follow-up of three years. Compared to women with either illness alone or neither, women with both GDM and NAFLD had substantially higher incidence rates per 100 woman-years (14.2). The prevalence of NAFLD, age over 35, postpartum overweight/obesity, and family history of diabetes were important indicators of glycaemic development. Cardiometabolic risk variables showed notable declines in females with NAFLD and GDM.

Conclusion: Females with GDM and NAFLD are at high risk for prediabetes and diabetes. Glycaemic progression is predicted by age, postpartum BMI, family history of diabetes, and NAFLD. These findings suggest targeted surveillance and early intervention to avoid diabetes and manage cardiometabolic hazards in this high-risk group.

Recommendations: Regular screening for glycaemic status and cardiometabolic risk factors should be prioritized in females with a history of GDM and NAFLD. Lifestyle interventions focusing on weight management and metabolic health are essential to reduce the progression to prediabetes and diabetes in this high-risk group.



How to Cite

Behera, R. R. ., & Kumari, M. . (2024). Incidence of Prediabetes and Diabetes in Women with Previous Gestational Diabetes and Non-Alcoholic Fatty Liver Disease: A Prospective Study. Student’s Journal of Health Research Africa, 5(6).



Section of General Medicine Research

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