SERUM ANTIOXIDANT DERANGEMENTS AS DIAGNOSTIC AND PROGNOSTIC MARKER IN BIPOLAR DISORDER

Authors

  • Narveer Yadav Assistant Professor, Department of Psychiatry, Government Medical College, Badaun, India
  • Aarti Yadav  Senior Resident, Department of Dermatology, Government Medical College, Badaun, India
  • Praveen Rikhari Assistant Professor, Department of Psychiatry, Himalayan Institute of Medical Sciences, Dehradun, India,
  • Vishal Sinha Professor, Department of Psychiatry, Sarojini Naidu Medical College, Agra, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i6.1246

Keywords:

Serum Antioxidant Derangements, Diagnostic And Prognostic, Bipolar Disorder

Abstract

Background: This study was undertaken to study the role of non-enzymatic antioxidants - serum uric acid, albumin, and bilirubin in different phases of bipolar disorder and compare them with healthy controls.

Method: This was a prospective observational study in which participants were divided into three groups. The first group comprised bipolar disorder patients with manic episode, second group included bipolar disorder patients with depressive episode, and the third group included healthy controls. The levels of serum uric acid, albumin and bilirubin were determined at baseline and after 4 weeks of treatment.

Results: A total of 107 participants were enrolled in the study, including 53 with bipolar mania, 24 with bipolar depression, and 30 healthy controls. Key findings include significantly higher uric acid levels in patients with bipolar mania compared to both bipolar depression and healthy controls. Conversely, serum albumin levels were lower in bipolar depression. Using correlation analyses, we noted that higher uric acid levels correlated positively with the number of mood episodes, duration of illness, and severity of manic symptoms while it was seen that in depressive episodes, uric acid levels correlated positively with episode duration. Changes in uric acid and albumin levels following treatment were also observed, with significant decreases noted in serum uric acid levels in manic episodes and an increase in albumin levels in depressive episodes.

Conclusion: These findings suggest a potential role for serum uric acid and albumin as biomarkers in bipolar disorder, reflecting oxidative stress in these patients. This might also have a role in monitoring the progress and treatment of the patients.

Recommendation: Further research with larger cohorts, consideration of confounding factors and including measurement of more antioxidant molecules is essential to validate these findings.

Published

2024-06-30

How to Cite

Yadav, N. ., Yadav, A. ., Rikhari, P. ., & Sinha, V. . (2024). SERUM ANTIOXIDANT DERANGEMENTS AS DIAGNOSTIC AND PROGNOSTIC MARKER IN BIPOLAR DISORDER. Student’s Journal of Health Research Africa, 5(6). https://doi.org/10.51168/sjhrafrica.v5i6.1246

Issue

Section

Section of Mental Health and Psychiatry