A retrospective study on acute renal damage during pregnancy and puberty

Abstract

Background: Acute kidney injury is uncommon in young women while pregnant and post-delivery care, but it is linked via higher deaths and morbidity.

Objective: This research aims to examine the prevalence, outcomes, and characteristics of AKI while pregnant and the post-delivery period in an Indian populace.

Methods: The present research examined pregnant women who were discharged from the hospital between 2022 to 2023. In expectant mothers who don't have a history of chronic kidney disease (CKD), AKI is described as serum creatinine levels exceeding 70.72umol/l. Acute-on-CKD is defined as a fifty percent rise in creatinine levels in the serum over baseline for individuals with pre-existing CKD.

Results: We found a high (0.81%) prevalence of AKI during pregnancy and post-delivery care. There were 172 patients of AKI during pregnancy and post-delivery care, including 10 cases of severe AKI and 11 cases of acute CKD. During pregnancy and the post-delivery period, the primary causes of acute kidney injury were hemorrhage after delivery and toxemia. Approximately 17% of women with toxemia and 60% with HELLP syndrome have complications with AKI. The outcome was favorable, except in cases of blockage in amniotic fluid, while the pregnancy outcome was generally poor. Four out of the seven fatal cases received replacement therapy for their kidneys. Pregnant women with AKI were most likely to die from amniotic fluid blockage or hemorrhage following delivery.

Conclusion: Acute renal damage a pregnant women and post-delivery care is more common than we previously thought. Toxemia is the most prevalent cause of severe kidney disease during pregnancy and post-delivery care. However, the outcome is favorable. Blockage of amniotic fluid and bleeding after delivery are the most prevalent causes of maternal death. Major Acute kidney injury may indicate an inadequate result.