POSITIVE CORRELATION OF CRP, FOLIC ACID AND D-DIMER WITH PROGRESSION OF CKD STAGING.

Authors

  • Afsha Mohi Ud din  PhD Scholar, Department of Biochemistry, SGRR Medical College and Hospital, Dehradun, India
  • Rana Usmani  Associate Professor, Department of Biochemistry, SGRR Medical College and Hospital, Dehradun, India
  • Vivek Ruhela Associate Professor, Department of Nephrology, SGRR Medical College and Hospital, Dehradun, India
  • Tariq Masood Professor, Department of Biochemistry, SGRR Medical College and Hospital, Dehradun, India
  • Farah Ahsan  Assistant Professor, Department of Biochemistry, SGRR Medical College and Hospital, Dehradun, India

DOI:

https://doi.org/10.51168/sjhrafrica.v5i3.1121

Keywords:

Chronic kidney disease, C-reactive protein, D-dimer, Folic acid

Abstract

Background:

Chronic kidney disease (CKD) is characterized by kidney damage or a decline in glomerular filtration rate (GFR) over a period of three months, often leading to various complications and stages of severity. Biomarkers such as C-reactive protein (CRP), D-dimer, and folic acid have been implicated in CKD progression, yet their correlation across different CKD stages remains to be fully elucidated. The study aims to do a comparative study of D-dimer, CRP, and Folic acid in different stages of chronic kidney disease.

Methods:

The study employed a cross-sectional design. Serum samples from 150 CKD patients were collected and analyzed for CRP, D-dimer, and folic acid levels using standard laboratory procedures. Statistical analysis was performed using SPSS software and Microsoft Excel to assess the significance of biomarker variations across CKD stages.

Results:

Analysis revealed significant differences in serum CRP, D-dimer, and folic acid levels among different CKD stages. Serum CRP and D-dimer levels were notably elevated in advanced CKD stages, while folic acid levels exhibited a contrasting pattern, with higher levels observed in earlier CKD stages.

Conclusion:

The study underscores the importance of monitoring biomarker levels in CKD progression, with CRP and D-dimer serving as potential indicators of disease severity. Additionally, the observed inverse relationship between folic acid levels and CKD staging warrants further investigation into its potential protective role against CKD progression.

Recommendations:

Clinicians should consider incorporating regular assessment of CRP, D-dimer, and folic acid levels into CKD management protocols to better understand disease progression and tailor treatment strategies accordingly.

Published

2024-03-31

How to Cite

din, A. M. U. ., Usmani, R. ., Ruhela, V. ., Masood, T. ., & Ahsan, F. . (2024). POSITIVE CORRELATION OF CRP, FOLIC ACID AND D-DIMER WITH PROGRESSION OF CKD STAGING. Student’s Journal of Health Research Africa, 5(3). https://doi.org/10.51168/sjhrafrica.v5i3.1121

Issue

Section

Section of Biochemistry