Prospective observational study on the incidence and risk factors for seroma formation following modified radical mastectomy.

Kritika  Jha; Kritika  Jha; Pankaj Kumar  Mishra; Binoy  Kumar

doi:10.51168/sjhrafrica.v7i3.2604

Authors

Piyush Kumar Sinha Senior Resident, Department of General surgery, Patna Medical College & Hospital, Patna, Bihar
Kritika Jha Senior resident, Department of General Surgery, Patna Medical College & Hospital, Patna, Bihar, India.
Pankaj Kumar Mishra Associate Professor, Department of General Surgery, Patna Medical Hospital, Patna, Bihar
Binoy Kumar Professor (HOD), Department of General Surgery, Patna Medical College & Hospital, Patna, Bihar

DOI:

https://doi.org/10.51168/sjhrafrica.v7i3.2604

Keywords:

Seroma formation, Modified Radical Mastectomy, Body Mass Index, Breast size, Surgical duration, body mass index, age, comorbidities

Abstract

Background:

Seroma formation is one of the most common complications following modified radical mastectomy (MRM), leading to discomfort and delayed recovery.

Objective:

To determine the incidence and identify risk factors associated with seroma formation following MRM.

Methods:

This prospective observational study was conducted over 7 months and included 103 patients undergoing MRM. Sociodemographic, clinical, and intraoperative variables were recorded. Statistical analysis was performed using chi-square and t-test, with p < 0.05 considered significant.

Results:

The mean age of participants was ___ years. The incidence of seroma was 36.9% (38/103). Significant risk factors included BMI >25 (70% vs 45%, p<0.05), large breast size (65% vs 40%, p<0.05), and surgery duration >120 minutes (60% vs 35%, p<0.05). Age and diabetes were not statistically significant.

Conclusion:

Seroma formation remains a frequent complication after MRM. Identification of modifiable risk factors, such as BMI and surgical duration, can help reduce incidence.

References

Hashemi E, Kaviani A, Najafi M, Ebrahimi M, Hooshmand H, Montazeri A. Seroma formation after surgery for breast cancer. World J Surg Oncol. 2004;2(44):1–5.

Kumar S, Paramba KL, Kumar A. Evaluation of risk factors for seroma formation following modified radical mastectomy at a tertiary care center in Jharkhand. Int J Acad Med Pharm. 2025;7(5):1199–202.

Sunil Kumar Neti, Siddhartha Sankar Pradhan SKM. Observational study on the incidence and risk factors for seroma formation following modified radical mastectomy. Int J Life Sci Biotechnol Pharma Res. 2025;14(10):1084–8.

S MR, Jayan NP, Basith A, Gopi E V, Ribin SM. Observational study on the incidence and risk factors for seroma formation following modified radical mastectomy. Professor and Head of the Department, Department of General Surgery, Government Medical College, Calicut, Received : 29-11-2021 / Revised. Int J Heal Clin Res. 2022;5(2):701–4.

Rani Sharma, Kumar Abhishek Ranjan, Pranava Dutta Verma RS. An observational study on the incidence and risk factors for seroma formation post-modified radical mastectomy. J Cardiovasc Dis Res. 2024;15(05):2080–8.

Chaudhary A, Gautam S. A prospective study of factors affecting seroma formation after modified radical mastectomy in patients of carcinoma of breast. Int Surg Journa. 2020;7(9):2919–24. https://doi.org/10.18203/2349-2902.isj20203768

Gaurav, Ashish Sahu TK. Observational Study on The Incidence and Risk Factors for Seroma Formation Following Modified Radical Mastectomy. Int J Curr Pharm Rev Res. 2025;17(3):2157–61.

Kumar A, Chumber S. The prevalence of seroma formation after modified radical mastectomy: an observational analysis of risk factors. Int J Res Med Sci. 2024;12(2):409–12. https://doi.org/10.18203/2320-6012.ijrms20240021

Singh J, Ghumman NS, Chawla AK, Singh A. Incidence and Risk Factors for Seroma Formation Following Modified Radical Mastectomy: A Retrospective Observational Study. Int J Curr Pharm Rev Res. 2025;17(9):727–32.